| 赵传磊,李天然,陈自谦,钱根年,陈锦华,王楷堂.[J].中国医学影像技术,2006,22(11):1745~1748 |
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| Whole body 18F-FDG PET/CT imaging for detection of primary tumor in cervical metastatic carcinoma of unknown primary site |
| 投稿时间：2006-09-15 修订日期：2006-09-20 |
| DOI： |
| 中文关键词: 转移癌 颈部 原发灶 体层摄影术,发射型计算机 体层摄影术,X线计算机 氟脱氧葡萄糖 F18 |
| 英文关键词:Metastatic carcinoma Cervical Primary lesion Tomography, emission-computed Tomography, X-ray computed Fluorodeoxyglucose F 18 |
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| 中文摘要: |
| 目的 初步探讨全身18氟 -FDG PET/CT在原发灶不明的颈部转移癌中的应用价值。方法 对42例原发灶不明的颈部转移癌患者行全身18F-FDG PET/CT检查,分别对单独PET图像、单独CT图像及PET/CT融合图像进行判读,所得结果与病理和/或随访结论比较。结果 PET/CT对原发灶检出率优于单独PET及单独CT(灵敏度分别为59.5％(25/42)、35.7%(15/42)、及23.8％(10/42),χ2值分别为8.100及13.067,P<0.01,均有显著统计学差异)。28.6％患者(12/42)经PET/CT检查后发现分期改变(包括4例未找到原发灶患者)。在29例已行颈部肿块切除病例中,有5例局部仍可见异常高代谢灶,提示肿瘤残余。PET/CT、单独PET及单独CT假阳性率分别为4.8％(2/42)、16.7％(7/42)及9.5％(4/42)。结论 18F-FDG PET/CT全身显像对于寻找原发灶不明的颈部转移癌患者的原发灶、了解肿瘤生物学特性及全身侵犯情况有重要的临床价值,有利于临床及时制定或调整治疗方案。 |
| 英文摘要: |
| Objective To retrospectively evaluate whole body 18F-FDG PET/CT in depicting the primary lesion in cervical metastatic carcinoma of unknown primary site (CCUP). Methods Forty-two CCUP patients were included and underwent whole body 18F-FDG PET/CT imaging to search the primary lesion. A radiologist and a nuclear medicine specialist performed blinded interpretation of PET alone, CT alone and dual-modality PET/CT imaging. Results The detection efficacy of dual-modality PET/CT was higher than PET alone and CT alone. The sensitivity was 59.5%(25/42), 35.7%(15/42) and 23.8%(10/42) respectively. Statistical Results showed the sensitivity of dual-modality PET/CT was higher than PET alone and CT alone (χ2 value was 8.100 and 13.067, P<0.01). The staging evaluation of 12 patients (28.6%, 12/42) was changed after whole body 18F-FDG PET/CT imaging (including 4 patients with no primary lesion found). There were still 5 hypermetabolism lesions in the 29 patients who had been undergone completely local lesion ablation. The false positive rate (FPR) of dual-modality PET/CT, PET alone and CT alone is 4.8%(2/42), 16.7%(7/42) and 9.5%(4/42) respectively. Conclusion Whole body 18F-FDG PET/CT may be of relatively higher value in identifying the primary tumor of CCUP patients compared with conventional imaging methods. It also may reveal tumor biology characteristics and display tumor involvement extent. |
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