| 谢春明,马林,方艳,李德军,富丽萍,孟海燕,邸秀珍,杨征.线索诱发海洛因渴求的功能磁共振成像研究[J].中国医学影像技术,2006,22(11):1642~1645 |
| 线索诱发海洛因渴求的功能磁共振成像研究 |
| Functional magnetic resonance imaging study on the cue-induced heroin craving |
| 投稿时间：2006-04-15 修订日期：2006-08-05 |
| DOI： |
| 中文关键词: 线索 海洛因渴求 磁共振成像,功能性 血氧水平依赖 |
| 英文关键词:Cue Heroin craving Magnetic resonance imaging, functional Blood oxygenation level dependence |
| 基金项目:美国NIH/NIDA资助项目(R01DA10214);国家973资助课题(2003CB515408)。 |
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| 中文摘要: |
| 目的 识别与线索诱发海洛因渴求相关的特异脑区的神经网络活动。方法 采用病例对照研究。选取海洛因依赖者和健康对照者各10人,在观看自然风光和海洛因相关录像时进行全脑磁共振(MRI) 扫描。比较:①不同受试组观看海洛因相关录像时激活脑区的差异, ②海洛因依赖者观看自然风光和海洛因相关录像时激活脑区的差异。应用功能性神经图像分析(AFNI)软件包进行数据分析。结果 ①观看海洛因相关录像时,海洛因依赖者与健康对照者相比左前额叶皮层激活最为明显。②海洛因依赖者观看海洛因相关录像与观看自然风光录像比较发现,左前扣带回、左额叶内侧回(BA10)、小脑山顶,中脑导水管旁灰质,以及右侧前楔叶可见显著激活。结论 线索诱发海洛因渴求的特异激活脑区集中在左前扣带回和左前额叶皮层。中脑导水管旁灰质可能参与渴求的产生与维持。 |
| 英文摘要: |
| Objective To detect neuronal network activity of specific brain areas in craving state induced by heroin related cues. Methods Ten right-handed heroin male patients and 10 healthy men were recruited in the case-control study. They were performed the whole brain scan with 1.5T MR scanner when presented with natural scenery and heroin related cues. The differences of brain areas activation were analyzed when two group subjects watched heroin related cues and heroin patients watched natural scene and heroin related cues, respectively. Data analysis were applied with Analysis of Functional NeuroImaging (AFNI) soft package. Results ①Brain activation in left prefrontal cortex was more obvious in heroin patients compared with healthy controls while presented with heroin related cues. ②When heroin patients watched heroin related cues and natural scenery, there were significant activated brain areas located mainly in the left anterior cingulated cortex, BA10, culmen of cerebellum, periaqueductal gray (PAG), and right precuneus. Conclusion The activation of specific brain areas in craving state induced by heroin related cues were located in the left anterior cingulated cortex and left prefrontal cortex. PAG may be involved in the formation and sustain of craving. |
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