| 于龙华,卢光明,张志强,邹萍.脑肿瘤致偏瘫患者患侧运动区定位的fMRI研究[J].中国医学影像技术,2006,22(11):1635~1637 |
| 脑肿瘤致偏瘫患者患侧运动区定位的fMRI研究 |
| fMRI study of motor cortex location in hemiparetic patients with brain tumors |
| 投稿时间：2006-08-08 修订日期：2006-09-18 |
| DOI： |
| 中文关键词: 磁共振成像,功能性 患侧 定位 运动区 |
| 英文关键词:Magnetic resonance imaging, functional Affected side Location Motor area |
| 基金项目: |
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| 摘要点击次数: 1931 |
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| 中文摘要: |
| 目的 采用功能磁共振成像技术对脑肿瘤致偏瘫患者患侧运动皮层进行定位研究。方法 选择7例运动皮层区域肿瘤致偏瘫患者,采用组块设计的方法,分别行健侧手、患侧手、双手同时的三种静止与对指任务,在GE Signa 1.5T磁共振成像仪下行数据采集,SPM99进行数据后处理,结果采用单样本分析,另选9例临床症状轻或无的该区域肿瘤患者作为对照。结果 对照组中每位病例不同任务下对比显示激活的PM区后方紧邻M1区。偏瘫患者组中仅有3例能完成含有患侧手的动作任务(42.9％),这3例患侧SMA、PM、M1区有激活。7例患者均完成了健侧手的动作任务,且有6例患侧辅助运动区、运动前区有激活(85.7％)。结论 偏瘫患者健侧手复杂对指时能激活患侧的辅助运动区和运动前区的位置,并可以PM区推断主运动区的位置,这在患侧手不能完成动作任务而患侧脑区不能定位时起到了较好的弥补作用。 |
| 英文摘要: |
| Objective To study the affected side motor cortex location in hemiparetic patients with brain tumors by using functional magnetic resonance imaging (fMRI). Methods Data was obtained from seven hemiparetic patients with brain tumors using BOLD-fMRI technique at GE Signa 1.5T MR system. Three block-paradigms were applied with the affected side and the unaffected and the both side fingers holding still or opposite respectively. Data processing was carried out using SPM99. The result was analyzed with single-subject model. Nine patients with little or without motor deficit were taken as the control group. Results Every patient in control group showed that the activation of M1 was behind the premoter (PM) area. But only three patients in the hemiparetic group could finish the affected and (or) the both side fingers movement (42.9%), the M1, supplemental motor area (SMA) and PM area of the affected side were activated. All the hemiparetic patients can finish the unaffected ipsilateral fingers task, six of them showed PM area of the affected side activated (85.7%). Conclusion fMRI can localize the PM area and SMA of the affected side in hemiparetic patients by using the unaffected ipsilateral hand, and it is possible to use PM area as functional landmark to identify the precentral gyrus on the tumors side. |
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