| 薛竞宜,杜国庆,田家玮,李悦.心力衰竭犬心房结构重构的实验研究[J].中国医学影像技术,2006,22(9):1313~1316 |
| 心力衰竭犬心房结构重构的实验研究 |
| Atrial structural remodeling in congestive heart failure canine |
| 投稿时间：2006-06-06 修订日期：2006-08-28 |
| DOI： |
| 中文关键词: 心力衰竭,充血性 心房颤动 心房 犬 |
| 英文关键词:Heart failure, congestive Fibrillation, atria Atrium Canine |
| 基金项目:黑龙江省卫生厅青年基金资助(2005-187)。 |
|
| 摘要点击次数: 1812 |
| 全文下载次数: 858 |
| 中文摘要: |
| 目的 观察右室快速起搏建立心力衰竭犬模型的效果,探讨心房结构重构在心力衰竭与心房颤动形成过程中的作用机制。方法 13只犬随机分为起搏组(n=7)和假手术组(n=6),于左、右心房各缝植4对电极,起搏电极缝植在右室心尖,连接实验用VOO型起搏器,快速心室起搏(220次/分)6周,建立心力衰竭犬模型,分别于起搏前、起搏6周后,应用经食管超声心动图测量左房收缩末容积;采用双平面Simpson法测量左室舒张期末和收缩期末容积,得出左室射血分数和心输出量,并应用光镜和电镜观察心房肌的超微结构。结果 ①假手术组术前和术后心脏各参数无明显变化。②起搏6周后,起搏组与假手术组比较,左房收缩末容积显著增大 ,左室舒张末期容积显著增大 ,左室收缩末期容积显著增大 ,射血分数显著降低 ,心输出量著降低 。③病理学结果显示起搏犬心房肌细胞变性、肌纤维溶解、线粒体肿胀以及间质胶原增生、水肿。结论 心房结构重构是心力衰竭犬发生心房颤动的重要原因。 |
| 英文摘要: |
| Objective To observe the effort of canines in heart failure model induced by rapid right ventricular pacing and investigate the mechanism of atrial structural remodeling in the formation of congestive heart failure and atrial fibrillation. Methods Thirteen canines were randomly divided into ventricular pacing group (n=7) and sham-operated group (n=6). Four pairs electrodes were sutured to four sites in each atrium. A pacemaker (VOO) was implanted in a subcutaneous pocket and attached to a screw-in epicardial lead in the apex of right ventricle. The canines in ventricular pacing group were paced at 220 beats per minute for 6 weeks. Before and after rapid ventricular pacing, transesophageal echocardiography was performed in 13 canines. Left atrial end-systolic volume (LAESV), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) were measured with bi-plane Simpson, and ejection fraction (EF) and cardiac output (CO) were calculated. Pathohistological and ultrastructural changes were tested by light microscope and transmission electron microscope. Results ①There were no changes of cardiac characteristics before and after the procedure in sham-operated group. ②In the ventricular pacing group, after 6 weeks rapid ventricular pacing, compared to the sham-operated group, LAESV was significantly increased , LVEDV was significantly increased , LVESV was significantly increased , EF was significantly decreased (31.4%±10.2% vs 56.8%±4.5%, P<0.01) and CO was significantly decreased . ③The characteristic pathological changes were found in ventricular pacing group, such as atrial myocardial cell degeneration, muscle fibronolysis, mitochondria swelling and numerous mesenchymal collagen edema. Conclusion Atrial structural remodeling may play an important role in the formation of atrial fibrillation in congestive heart failure. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
