| 张帆,李坤成,于春水,常丽荣,秦文.Mn2+增强磁共振成像对视神经损伤的观察[J].中国医学影像技术,2006,22(9):1310~1312 |
| Mn2+增强磁共振成像对视神经损伤的观察 |
| Manganese-enhanced MR imaging for optic never injury |
| 投稿时间：2006-04-06 修订日期：2006-07-25 |
| DOI： |
| 中文关键词: 视神经 锰 磁共振成像 损伤 |
| 英文关键词:Optic never Manganese Magnetic resonance imaging Injury |
| 基金项目:国家自然科学基金资助项目(30470519);北京市科技新星资助项目(2005B21)。 |
|
| 摘要点击次数: 2529 |
| 全文下载次数: 1044 |
| 中文摘要: |
| 目的 探讨活体视神经损伤不同时期Mn2+增强磁共振影像表现,为活体状态下研究神经损伤的形态学改变提供一种新的方法。方法 Wistar大鼠18只,随机分为3组,正常视神经组、视神经损伤24 h组和视神经损伤2周组,每组6只。分别在左侧眼球的玻璃体内注入浓度为0.8 mmol/L的MnCl2 2 μl,24 h后用1.5T磁共振仪进行扫描。结果 正常视神经显示了完整的走行,同时可以看到视觉传导通路的中继核团外侧膝状体和前丘的明显强化;视神经损伤24 h后,可见视神经的强化信号弥散,外侧膝状体和前丘的MnCl2最大增强信号及SNR(信噪比)降低;视神经损伤2周组,视神经走行显示不全,外侧膝状体和前丘的MnCl2最大增强信号明显减低及SNR的明显降低。三组在外侧膝状体和前丘Mn2+最大增强信号及SNR的两两比较上均有显著性的差异(P<0.001)。结论 Mn2+增强磁共振成像能够很好地评价视神经不同损伤时期的形态学改变,是活体状态下研究神经损伤的一种有效方法。 |
| 英文摘要: |
| Objective To investigate manganese-enhanced MR imaging of optic never injury and provide a new method for morphologic study of never injury in vivo. Methods Eighteen adult Wistar rats were randomly divided into 3 groups: normal, 24 h after injury, and 2 weeks after injury, 6 rats in each group. 2 μl volume of 0.8 mmol/L aqueous solution of MnCl2 was injected into the vitreous body of the left eye respectively. MRI studies were performed at 24 h after Mn2+ administration. Results Manganese-enhanced normal optic tracts, lateral geniculate nucleus and superior colliculus can be seen perfectly after Mn2+ administration. After optic never injury 24 h, enhanced signal and SNR (signal to noise) of lateral geniculate nucleus and superior colliculus by Mn2+ was decreased. After optic never injury 2 weeks, optic tracts can not be displayed integrallty. Meanwhile, enhanced signal and SNR of lateral geniculate nucleus and superior colliculus by Mn2+ was decreased markedly. Three groups showed significant difference in enhanced signal and SNR (P<0.001). Conclusion Manganese-enhanced MR imaging can evaluate morphological fashion of optic never in different injury times. It is an effective method to monitor never injuries in vivo. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
