| 贺小红,冯彦林,黄克敏,余丰文,杨明.18F-FDG标准化摄取值在不同衰减校正方式中的比较研究[J].中国医学影像技术,2006,22(8):1251~1254 |
| 18F-FDG标准化摄取值在不同衰减校正方式中的比较研究 |
| Comparison of standard uptake value of 18F-FDG in different attenuation correction modes |
| 投稿时间：2006-02-21 修订日期：2006-05-15 |
| DOI： |
| 中文关键词: 体层摄影术,发射型计算机 体层摄影术,X线计算机 标准化摄取值 衰减校正 氟脱氧葡萄糖 F18 |
| 英文关键词:Tomography, emission-computed Tomography, X-ray computed Standard uptake value Attenuation correction Fluorodeoxyglucose F18 |
| 基金项目: |
|
| 摘要点击次数: 2956 |
| 全文下载次数: 1723 |
| 中文摘要: |
| 目的 比较应用X线CT和137Cs透射数据对PET发射数据进行衰减校正时,标准化摄取值(SUV)的差异。方法 以Philips圆柱体空心SUV校正模型和20例患者为研究对象,在PET/CT全身三维显像模式中,分别用X线CT和137Cs透射数据做PET发射数据的衰减校正(CTAC和CsAC)。分别在CTAC及CsAC均匀水模的中心15层横断面图像的相同位置,以及所有患者相同部位的肌肉、脂肪、肠道、肝脏、肺、心肌、脑、骨等不同密度的正常组织中,划取相同大小的感兴趣区(ROI),通过计算机自动测量各ROI的平均SUV,并在CT横断面图像的相应位置测量人体组织的平均CT值。然后将所有被测人体组织分为软组织和骨组织两组,分别比较分析各组中CTAC和CsAC平均SUV的差异,及这种差异与CT值的相关性。全部采用临床全身显像的三维重建算法来重建图像。结果 模型研究结果:在不同活性时,CsAC方式均能得到稳定可靠的SUV。而CTAC方式得到的SUV随着放射性活性水平降低,有逐渐升高的趋势。 在单位活度6.253 MBq/kg至4.292 MBq/kg之间,即制造商推荐的标准给药活性(5.18 MBq/kg体重)附近,CTAC和CsAC方式测得的SUV相同;患者研究结果:除脑组织以外的所有软组织中,CTAC的平均SUV较CsAC者低17%(t=-5.328, P=0.000),相应部位所测得的CT值为-850~68 Hu ,平均SUV的差异与相应的CT值呈负相关(r=-0.237, P=0.000);在骨组织中,CTAC的平均SUV较CsAC者高16% (t=7.960, P=0.000),相应部位所测得的CT值为105~550 Hu ,平均SUV的差异与相应的CT值呈正相关(r=0.539, P=0.000)。结论 ①不同活性水平时,CsAC方式的SUV稳定、可靠,而CTAC方式的SUV稳定性和可靠性差;②模型模拟标准临床显像程序来测试PET/CT定量指标的稳定性具有明确的实用价值;③呼吸运动和组织衰减系数由低能向高能转换过程所带来的误差等,也是影响CTAC方式SUV稳定性的主要因素。 |
| 英文摘要: |
| Objective To compare standard uptake value (SUV) in 137Cs attenuation correction (CsAC) and X-ray CT attenuation correction (CTAC) with Gemini PET/CT imaging. Methods A Philips hollow SUV calibration phantom and 20 patients were imaged, in which whole body 3D imaging mode used for data acquisition and image reconstruction with both CTAC and CsAC modes. Regions of interest (ROIs) were draw on the central 15 transverse slices of the phantom images and on the transverse images of the 20 patients in different tissue regions, such as muscle, fat, colorectal, liver, myocardial, lung, brain and bone, for calculating the average SUVs of uniformity phantom and human body images, respectively. The differences of the SUVs with both CTAC and CsAC modes of the phantom were analyzed and compared. Average SUVs in the ROIs of each sort of tissue were calculated by the computer automatically from the 20 patients, and then divided into two groups of bone and non-bone. The differences of SUVs of different tissues between the CTAC and CsAC mode in each group were analyzed, and the relationship of the differences of SUVs to the corresponding CT values were also analyzed. Results The phantom studies showed that the SUVs of CsAC mode were more stationary than that of the CTAC in different activity level. The SUVs were equal in CTAC and CsAC with the activity level from 6.253 MBq/kg to 4.292 MBq/kg, which the average value was similar with that of the manufacturer prompted (5.18 MBq/kg). The SUVs from CTAC mode were increased as the activity level decreased. The patient studies showed that the average SUVs obtained with CTAC were 17% (t=-5.328, P=0.000) lower than that with CsAC in non-bone tissues excepted the brain, while they were 16% (t=7.960, P=0.000) higher with CTAC than that with CsAC in bone regions, and also, visual artifacts were found in the CTAC images of the high density contrast regions, where were normal in the CsAC images of the same regions. Conclusion ①The SUVs of CsAC mode were more stationary with different activity level than that of CTAC. ②Phantom studies using clinical protocols were very helpful in PET/CT clinical quality assurance practice. ③Emission and transmission data mis-registration and segmentation ratio from lower energy to higher energy may also be the main factors of impaction of the SUVs with CTAC mode. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
