| 李淑宇,蒲放,蒋田仔,刘爱珍,谢晟,王荫华.阿尔茨海默病脑灰质体积异常的MRI研究[J].中国医学影像技术,2006,22(8):1162~1164 |
| 阿尔茨海默病脑灰质体积异常的MRI研究 |
| MRI study on abnormal gray matter volume in Alzheimer's disease |
| 投稿时间：2006-05-30 修订日期：2006-07-30 |
| DOI： |
| 中文关键词: 灰质 磁共振成像 阿尔茨海默病 基于体素的形态学分析 |
| 英文关键词:Gray matter Magnetic resonance imaging Alzheimer's disease Voxel-based morphometry |
| 基金项目:本研究得到国家自然科学基金项目(60121302),北京市自然科学基金(3052009,3063024)资助。 |
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| 中文摘要: |
| 目的 研究阿尔茨海默病(AD)患者MRI图像脑灰质萎缩的模式。方法 对19例AD患者和20例正常老年对照者行MRI扫描,通过优化的基于体素的形态学(optimized voxel-based mophometry, OVBM)分析方法,分析AD患者全脑和局部脑灰质的体积异常。结果 AD患者全脑灰质体积相对于正常对照者明显降低(P＝0.0048),双侧海马、双侧丘脑、双侧颞上回和左侧颞中回体积明显减少(多重校正后,相当于P<0.05)。结论 AD患者的全脑灰质体积明显降低,局部区域明显萎缩。 |
| 英文摘要: |
| Objective To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion The global and local gray matter volumes of AD have markedly reduced. |
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