| 张帆,李坤成,于春水,常丽荣,秦文.Mn2+增强磁共振扫描对视觉传导通路及皮层投射的显示[J].中国医学影像技术,2006,22(8):1140~1142 |
| Mn2+增强磁共振扫描对视觉传导通路及皮层投射的显示 |
| Manganese-enhanced MR imaging for demonstration of optic never pathway and cerebral projection |
| 投稿时间：2006-02-20 修订日期：2006-08-07 |
| DOI： |
| 中文关键词: 锰 磁共振成像 视觉传导通路 |
| 英文关键词:Manganese Magnetic resonance imaging Optic nerve pathway |
| 基金项目:国家自然科学基金项目资助(30470519)、北京市科技新星项目资助 (2005B21)。 |
|
| 摘要点击次数: 2522 |
| 全文下载次数: 1008 |
| 中文摘要: |
| 目的 探讨Mn2+增强磁共振扫描对活体大鼠视觉传导通路及皮层投射的显示以及眼球玻璃体内Mn2+的浓度对跨节转运的影响。方法 6只Wister大鼠,随机分为两组,每组3只,一组左侧眼球玻璃体内注射0.8 mmol/L MnCl2 2 μl,一组左侧眼球玻璃体内注射1.6 mmol/L MnCl2 2 μl,用1.5T超导磁共振扫描,观察视觉传导通路的显示;一周后6只大鼠右侧外侧膝状体注射1 mmol/L MnCl2 1 μl,观察视觉皮层的定位。结果 眼球玻璃体内注射不同浓度MnCl2 10 h后行磁共振扫描,完整地显示了活体大鼠的视觉传导通路从视神经、视交叉、视束至外侧膝状体和上丘的走行,但均没有观察到从外侧膝状体向视皮层的投射;而在外侧膝状体注射1 mmol/L MnCl2 4 h后可以看到视皮层的明显强化。结论 大鼠眼玻璃体和外侧膝状体注射Mn2+后,清晰的显示增强的视觉传导从视神经至外侧膝状体和上丘的走行,以及外侧膝状体向大脑皮层的投射,视觉传导束路和视觉皮层投射的定位与三维坐标图谱的解剖定位一致;眼球玻璃体内Mn2+的浓度对跨节转运没有影响。 |
| 英文摘要: |
| Objective To investigate in vivo MRI detection of axonal transport for tracing optic nerve pathway and cerebral projection as well as effect of MnCl2 concentration in the vitreous body for transsynaptic crossing. Methods Six adult Wistar rats were randomly divided into two groups: group A (n=3) and group B (n=3). 2 μl volume of 0.8 mmol/L and that of 1.6 mmol/L aqueous solution of MnCl2 was injected into the vitreous body of the left eye of group A and group B respectively. MRI studies were performed at 10 h after Mn2+ administration to observe optic nerve pathway, one week later, 1 mmol/L aqueous solution of MnCl2 was injected into the lateral geniculate nucleus of all six Wistar rats for observing optic radiation cerebral projection. Results Manganese-enhanced normal optic tracts, lateral geniculate nucleus and superior colliculus can be seen perfectly after 10 h of the vitreous body Mn2+ administration. But there were no enhanced signal in optic cortex at two group. Manganese-enhanced cerebral projection can be seen after 4 h of the lateral geniculate Mn2+ administration. Conclusion Manganese-enhanced magnetic resonance imaging can show neuroanatomic tract tracing, and result is consistency with rats anatomy atlas. Mn2+ concentration in the vitreous body have no relation with transsynaptic crossing in the lateral geniculate nucleus. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
