| 张蕾,CatherineMandel,杨振燕,QingYang,RichardNibbs,DavidWesterman,AlexGPitman.动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究[J].中国医学影像技术,2006,22(7):1074~1078 |
| 动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究 |
| Signs of tumor infiltration of bone marrow in patients with hematological malignancies on dynamic contrast-enhanced MR imaging: preliminary results |
| 投稿时间：2006-02-27 修订日期：2006-05-08 |
| DOI： |
| 中文关键词: 磁共振成像,动态增强 血液病 骨髓 |
| 英文关键词:Magnetic resonance imaging Hematologic diseases Bone marrow |
| 基金项目: |
| 作者 | 单位 | E-mail | | 张蕾 | 同济大学附属同济医院放射科,上海 200065 | zhanglei4302@hotmail.com | | CatherineMandel | Department of Radiology, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia | | | 杨振燕 | 同济大学附属同济医院放射科,上海 200065 | | | QingYang | Howard Florey Institute of Physiology and Experimental Medicine, the University of Melbourne, Melbourne, VIC 3010, Australia | | | RichardNibbs | Department of Radiology, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia | | | DavidWesterman | Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia | | | AlexGPitman | Department of Radiology, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia | |
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| 中文摘要: |
| 目的 本研究旨在利用动态增强MR成像技术(DCE-MR)检测血液病患者骨髓强化特征变化,研究其与骨髓肿瘤细胞浸润状态的相关性。方法 25例血液病经DCE-MR成像及髂嵴穿刺活检,测定骨髓灌注的最大强化率(PER),最大强化斜率值(Slopemax),峰值时间(TTP), 平均时间(MT), 以及骨髓活检分析肿瘤分数(TF)。结果 肿瘤浸润组较缓解期组PER高(临床缓解期为0.252±0.156,肿瘤组为0.592±0.433),统计学上有显著性差异(P<0.05)。肿瘤浸润组较缓解期组的Slopemax高 、TTP缩短 ,但统计学上无显著性差异(P>0.05),MT值两组差异不明显(P>0.05)。结论 动态增强MR成像能够监测血液病骨髓肿瘤细胞浸润状态,为恶性血液病治疗随访提供了一种新的无创性监测手段。 |
| 英文摘要: |
| Objective Using dynamic contrast-enhanced MR imaging (DCE-MRI) to evaluate the bone marrow status, and to determine whether several calculated parameters derived from the DCE-MRI correlate with the marrow's histological characteristics, especially with the tumor fraction. Methods DCE-MRI results were obtained from 25 patients with proven or known hematological malignancies about to undergo bone marrow biopsy of the posterior iliac crest. MRI examination of the area to be biopsied was done approximately one hour prior to the bone marrow biopsy. Time-signal intensity curves (TIC) were generated from the region of the iliac crest corresponding to the planned biopsy site. Enhancement parameters were calculated, including peak enhancement ratio (PER), maximum enhancement slope (Slopemax), time to peak (TTP) and mean time (MT). The biopsy specimen was reported synoptically, with relevant reported parametersincluding cellularity and tumor fraction (TF). Results PER values were significantly higher for the bone marrow tumor infiltration group than for the normal bone marrow group (P<0.05). A significant positive correlation was found between PER and TF, Slopemax and TF. A negative correlation was found between TTP and TF. But mean TTP and MT values for the bone marrow tumor infiltration group and the normal bone marrow group did not differ significantly. Conclusion Our preliminary findings suggest that the presence of diffuse bone marrow infiltration in patients with hematological malignancies can be verified using DCE-MRI. |
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