| 陆菁菁,王含,冯逢,付海鸿,金征宇,崔丽英.磁共振扩散张量成像用于多系统萎缩患者黑质纹状体投射的初步研究[J].中国医学影像技术,2006,22(7):990~993 |
| 磁共振扩散张量成像用于多系统萎缩患者黑质纹状体投射的初步研究 |
| Quantitative evaluation of the nigrostriatal projection in multiple system atrophy by MR diffusion tensor imaging: a preliminary study |
| 投稿时间：2006-01-10 修订日期：2006-04-21 |
| DOI： |
| 中文关键词: 多系统萎缩 黑质纹状体投射 磁共振成像 扩散张量成像 |
| 英文关键词:Multiple system atrophy Nigrostriatal projection Magnetic resonance imaging Diffusion tensor imaging |
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| 中文摘要: |
| 目的 探讨MR扩散张量成像(DTI)部分各向异性分数值(FA)在多系统萎缩(MSA)诊断中的价值。方法 对12例临床确诊的MSA患者和10例正常人行头颅常规MRI和DTI扫描,使用3.0T MR机和自旋回波-回波平面成像序列,b值为1000 s/mm2,扩散敏感梯度方向为25。测量所有受试对象的双侧苍白球、壳核、尾状核头及黑质外1/3处的FA值,并作统计学分析。结果 常规MRI见4例在T2像上壳核显示裂隙状高信号,其中1例合并T2像上壳核和尾状核弥漫信号增高。3例示桥脑及小脑严重萎缩,1例合并桥脑类"十"字形的T2像上高信号改变,另2例示小脑蚓部及半球中度萎缩。4例可见轻-中度额叶及颞叶萎缩。病变组FA值在苍白球及黑质外1/3处均明显低于对照组,而在尾状核头部的FA值与对照组无显著差异,在壳核高于对照组。结论 常规MRI对MSA的诊断价值有限。MSA患者在黑质纹状体投射局部的FA值较正常人下降,提示其存在的病理改变。DTI可在活体无创地评价黑质纹状体投射的病变,有较高的应用价值和潜能。 |
| 英文摘要: |
| Objective To assess the diagnostic value of MR diffusion tensor imaging (DTI) in multiple system atrophy (MSA). Methods Conventional MRI and DTI were performed in 12 clinically proved MSA patients and 10 age-matched normal controls using 3.0 T MR scanner. SE-EPI sequence was used. The b value was 1000 s/mm2, the number of diffusion sensitive gradient direction was 25. For quantitative assessment of the nigrostriatal projection, FA value of the bilateral globus pallidus, putamen, head of caudate nucleus and substantia nigra were measured and compared between the patients and the controls. Results Slit-like high signal at the putamen in T2WI was demonstrated in 4 patients, and 1 of the 4 patients also showed diffuse high signal change at the putamen and the caudate in T2WI. Severe infratentorial atrophy was demonstrated in 3 patients, together with cruciform high signal change at the pons in T2WI in 1 patient, and moderate cerebellar atrophy was shown in the other 2 patients. Mild atrophy in parietal and temporal lobes was demonstrated in 4 patients. The FA values of the MSA patients were significantly lower than those of the controls in the globus pallidus and the substantia nigra regions, but not in the head of the caudate nucleus region. The FA values in the putamen were significantly higher compared to those of the controls. Conclusion The value of conventional MRI was limited in the assessment of MSA. The FA values of the nigrostriatal projection in MSA patients were decreased, indicating the underlying pathology. DTI is a practical and promising method to noninvasively evaluate the nigrostriatal projection. |
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