| 李德鹏,李坤成,马云川,苏玉盛,张琳瑛,尚建文.胶质瘤的 18F-FDG PET影像分析[J].中国医学影像技术,2006,22(6):941~944 |
| 胶质瘤的 18F-FDG PET影像分析 |
| Analysis of 18F-FDG PET imaging of patients with gliomas |
| 投稿时间：2005-12-24 修订日期：2006-04-18 |
| DOI： |
| 中文关键词: 胶质瘤 发射型计算机,体层摄影术 氟代脱氧葡萄糖 |
| 英文关键词:Gliomas Emission-computed, tomography 18F-fluorodeoxyglucose |
| 基金项目: |
|
| 摘要点击次数: 2452 |
| 全文下载次数: 1543 |
| 中文摘要: |
| 目的 分析不同病理类型胶质瘤18F-FDG PET影像特征,提高其对胶质瘤术前诊断和术后复发与放射坏死鉴别诊断准确率。方法 经病理证实的胶质瘤84例,包括星形细胞瘤为56例,少突胶质细胞瘤15例,WHO Ⅱ混合性胶质瘤8例, WHO Ⅱ室管膜瘤5例。采用Siemens ECAT 47 PET扫描仪行术前 18F-FDG PET脑显像。目视法观察胶质瘤肿瘤灶 18F-FDG分布,采用ROI,与对侧对应正常部位比较,判断病灶的代谢程度。结果 56例星形细胞瘤中,WHO Ⅰ级6例 18F-FDG分布低于对侧相应部位的分布。Ⅱ级21例、Ⅲ级13例和Ⅵ级16例呈不同程度的 18F-FDG摄取增高。15例少突胶质细胞瘤中,WHO Ⅱ级11例呈 18F-FDG摄取减低。Ⅲ级4例呈 18F-FDG摄取明显增高。WHO Ⅱ级混合性胶质瘤8例和室管膜瘤5例,都呈 18F-FDG摄取增高。根据胶质瘤对 18F-FDG摄取程度,可将病灶分为代谢减低灶和增高灶两类。Ⅰ级星形细胞瘤和Ⅱ级少突胶质瘤为 18F-FDG摄取减低灶。星形细胞瘤Ⅱ、Ⅲ、Ⅳ级,Ⅱ级混合性胶质瘤,Ⅱ级室管膜瘤,Ⅲ级少突胶质细胞瘤为 18F-FDG摄取增高灶。不同级别星形细胞瘤和不同级别的少突胶质瘤的T/C,T/WM有明显差异,两两比较,P值都<0.01。结论 胶质瘤对 18F-FDG摄取程度与肿瘤病理类型和肿瘤恶性程度有关, 18F-FDG PET可用于胶质瘤分级。根据对 18F-FDG的摄取程度,胶质瘤可分为高代谢灶和低代谢灶两类, 18F-FDG PET可用于高代谢胶质瘤的诊断与术后复发与放射坏死的鉴别,不能用于低代谢灶的诊断与鉴别诊断。 |
| 英文摘要: |
| Objective Analyzing the characteristics of 18F-FDG PET imaging to improve accuracy in preoperative diagnosis and differentiation of postoperative recurrence from radiation necrosis in gliomas. Methods 84 were composed of 56 cases with astrocytic tumor, 15 with oligodendroglial tumor, 8 with mixed glioma and 5 with ependymal tumor. All of them had definite postoperative pathology results. 18F-FDG PET scan was performed before operation. After getting images, distribution of 18F-FDG was visually viewed. Meanwhile, ratios of T/WM(Tumor/white matter) and T/C(Tumor/Cortex) were measured, respectively. Results Compared with normal contralateral corresponding region, there was a decrease of uptake of 18F-FDG in 6 cases with astrocytoma WHO grade I. There was an increased accumulation of 18F-FDG in other 50 cases with astrocytomas. Lesions in 8 mixed gliomas WHO grade Ⅱ and 5 ependymomas WHO grade Ⅱ also presented with high uptake of 18F-FDG. Uptake of 18F-FDG in 4 patients with anaplastic oligodendroglioma WHO grade Ⅲ was high, while 11 with oligodendroglioma WHO grade Ⅱ presented with hypometabolism in 18F-FDG PET. According to different uptake of 18F-FDG, it was reasonable to classify all lesions into two groups. Lesions with oligodendroglioma WHO grade Ⅱ and astrocytoma WHO grade I belonged to low uptake of 18F-FDG group, other lesions belonged to high uptake of 18F-FDG group. Meanwhile, there was a significant difference in uptake of 18F-FDG between different grade astrocytomas and oligodendrogliomas (P<0.01). The more malignant gliomas were, the more uptake of 18F-FDG was. Conclusion Uptake degree of 18F-FDG varied with pathology and malignancy in gliomas, 18F-FDG PET could be used to grade gliomas. All lesions could be classified into hypometabolism and hypermetabolism according accumulation of 18F-FDG, 18F-FDG PET could be used to make a diagnosis and differentiate recurrence from radiation necrosis in gliomas with hypermetabolism, but could not be used to do them in gliomas with hypometabolism. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
