| 卢洁,李坤成,焦立群,凌峰.MR脑灌注成像评价颈内/大脑中动脉狭窄与闭塞的外科治疗[J].中国医学影像技术,2006,22(6):841~844 |
| MR脑灌注成像评价颈内/大脑中动脉狭窄与闭塞的外科治疗 |
| MR perfusion-weighted imaging for evaluation of surgery treatment in patients with ICA/MCA stenosis or occlusion |
| 投稿时间：2006-01-19 修订日期：2006-05-09 |
| DOI： |
| 中文关键词: 颈内动脉 大脑中动脉 狭窄,闭塞 磁共振成像 灌注 |
| 英文关键词:Internal carotid artery Middle cerebral artery Stenosis, occlusion Magnetic resonance imaging Perfusion |
| 基金项目:本课题受北京市优秀人才培养资助项目资助(20042D0501809)。 |
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| 中文摘要: |
| 目的 对外科和介入治疗前后ICA/MCA慢性重度狭窄或闭塞患者的脑灌注成像进行比较分析,探讨其对疗效评价的应用。方法 23例单侧慢性ICA/MCA重度狭窄或闭塞患者,分别于外科或介入治疗前后行MR脑灌注成像检查,计算脑灌注参数图,包括rCBF、rCBV、rMTT和TTP,对治疗前后脑灌注参数进行定性和定量比较分析。23例患者中10例行STA-MCA吻合术,10例行PTAS,3例行CEA。10例行STA-MCA吻合术中6例为MCA闭塞,4例为ICA闭塞;10例行PTAS中7例为ICA重度狭窄,3例MCA重度狭窄;3例行CEA均为ICA重度狭窄。结果 23例慢性ICA/MCA重度狭窄或闭塞患者,治疗前TTP、rMTT图均发现病变侧灌注延迟,而rCBF、rCBV图改变不明显,治疗后TTP、rMTT图上灌注异常区较治疗前减小,有显著性差异(P<0.01),rCBF和rCBV图与术前比较均无明显变化。治疗后病变区TTP、rMTT值较治疗前减低,有显著性差异(P<0.01),rCBF和rCBV值无显著性差异(P>0.05)。结论 PWI检查能够观察外科和介入治疗前后脑灌注的改善情况,为评价疗效提供影像学依据。 |
| 英文摘要: |
| Objective To assess the utility of perfusion-weighted imaging (PWI) for evaluating cerebral hemodynamic changes before and after surgery or interventional therapy in patients with unilateral ICA/MCA high-grade stenosis or occlusion. Methods PWI was performed on 23 patients with unilateral ICA /MCA high-grade stenosis or occlusion. The cerebral perfusion parameters such as rCBF, rCBV, rMTT and TTP were calculated. 10 patients underwent STA-MCA anastomosis, 10 patients underwent PTAS and 3 patients underwent CEA. Results The abnormal perfusion findings were depicted in 23 patients with ICA/MCA high-grade stenosis or occlusion. The values of TTP and rMTT were decreased after therapy, and the difference was statistically significant (P<0.01). However, there was no statistically significant difference between the values of rCBF and rCBV before and after therapy (P>0.05). The extents of abnormal perfusion were decreased on TTP and rMTT maps after therapy, and the differences were statistically significant (P<0.01). Conclusion PWI examination can depict the improved situation of cerebral perfusion after surgery or interventional therapy, and provided the basis of imaging for evaluating curative effect. |
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