| 彭淼,郭启勇,刘加成,于兵,孙宝海,权松民,范国光,韩继阳,王玉凤.Stroop任务的执行加工成分及其神经机制的功能磁共振研究[J].中国医学影像技术,2006,22(6):836~840 |
| Stroop任务的执行加工成分及其神经机制的功能磁共振研究 |
| Functional MRI study of the neural mechanism of component processing during Stroop task performance |
| 投稿时间：2006-02-23 修订日期：2006-05-12 |
| DOI： |
| 中文关键词: 磁共振成像,功能性 认知控制 前额叶 反应抑制 |
| 英文关键词:Magnetic resonance imaging, functional Cognitive control Prefrontal cortex Response inhibition |
| 基金项目:本研究受国家自然科学基金课题资助(30370502)和辽宁省教委基金课题资助(202013138)。 |
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| 中文摘要: |
| 目的 采用事件相关功能磁共振(ER-fMRI)方法研究Stroop任务的执行加工成分及其相应的神经机制。方法 对16例右利手的健康志愿者进行了冲突试次分别占不同比例的两种任务条件的Stroop色词-颜色命名任务。其中一种任务条件冲突试次占30%,一致试次占70%;另一种任务条件冲突试次占70%,一致试次占30%;,同时采用Phillips 3.0 T成像系统,采集其脑部的fMRI数据,图像后处理和分析采用SPM5分析软件得到脑功能活动的图像。结果 16例被试者中12例的资料符合研究条件而被采用。①两种Stroop任务条件的脑激活区域没有差别,与有关实验结果类似。②被试对两种任条件中的冲突试次分别形成了不同等级的冲突和策略加工,高冲突、低策略条件表现为左侧前扣带回(ACC),双侧VLPFC,双侧额极,双侧视区,左侧中颞叶,右侧顶下小叶(IPL),双侧小脑激活增强;高策略、低冲突条件右侧DLPFC,左侧SMA,右侧岛叶,双侧梭状回,右侧丘脑激活增强。③高抑制加工相应于VLPFC激活增强。结论 揭示认知控制加工需要扣带-前额通路在内的PFC内不同亚区的功能协同,支持DLPFC和ACC的功能分离,提示抑制功能可能与控制加工分离。 |
| 英文摘要: |
| Objective To identify the neural mechanism of component processing during Stroop task performance, investigate the possible interaction of different regions in PFC with event-related functional MRI (ER-fMRI). Methods Sixteen right-handed healthy volunteers performed two kinds of variant Stroop color naming paradigms, one of which comprising 30% incongruent trials and 70% congruent trials and another comprising 70% incongruent trials and 30% congruent trials. The fMRI data were collected on Phillips 3.0 T MRI systems and analyzed by SPM5 to generate the activation map. Results The data sets from 12 of 16 subjects were used in the study. ①There were no significant different functional localizations between two conditions of Stroop task, which were consistent with previous imaging researches. ② Condition 1 formed high level conflict processing and low level control processing for incongruent trials, corresponding with significantly activated in left ACC, bilateral VLPFC, bilateral frontopolar, bilateral visual association cortex, left medial temporal cortex and left IPL. Condition 2 formed high level control processing and low level conflict processing for incongruent trials, corresponding with significantly activated in right DLPFC, left SMA, right insular, bilateral fuisform gyrus and bilateral cerebellum. ③ VLPFC were significantly activated corresponding with high level inhibitory processing. Conclusion Functional dissociation between DLPFC and ACC suggested interaction among subregions in cingulo-frontal network. Inhibitory control maybe independent from central manipulated processing. |
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