| 吴光耀,雷皓,孙骏谟,田志雄,黄雄.结节性硬化症中皮质结节的质子磁共振波谱分析[J].中国医学影像技术,2006,22(6):826~828 |
| 结节性硬化症中皮质结节的质子磁共振波谱分析 |
| Analysis on proton MR spectroscopy of cortical tubers with tuberous sclerosis |
| 投稿时间：2005-11-16 修订日期：2006-02-15 |
| DOI： |
| 中文关键词: 结节性硬化症 皮质结节 质子磁共振波谱 |
| 英文关键词:Tuberous sclerosis Cortical tuber Proton MR spectroscopy |
| 基金项目:国家自然科学基金资助项目(30400136);湖北省卫生厅资助课题(301140319)。 |
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| 中文摘要: |
| 目的 分析结节性硬化症病人皮质结节的质子磁共振波谱特征,理解皮质结节的病理形成。方法 收集我院有完整波谱资料的25例临床确诊结节性硬化症病人,单体素质子磁共振波谱采集皮质结节和对侧半球MRI正常的对应脑区,比较两侧代谢物和各代谢物与Cr比值。结果 25例病人采集50个单体素波谱,均未显示Lac峰,两侧Cr峰对称。25例皮质结节NAA峰较对侧低,NAA/Cr值1.33~1.57,平均NAA/Cr值(1.46±0.07);正常对侧1.49~1.78,平均NAA/Cr (1.54±0.11) (t=3.024, P=0.004)。25例皮质结节Cho/Cr值(1.02±0.12),正常对侧是(1.00±0.15)(t=0.339, P=0.736)。结论 结节性硬化症皮质结节NAA/Cr降低,Cho峰无明显升高,反映皮质结节NAA减少,提示皮质结节是由不成熟神经元和/或没有NAA表达的神经胶质组成的病理特征。 |
| 英文摘要: |
| Objective To analyze the feature of proton MR spectroscopy (1H MRS) of cortical tubers in tuberous sclerosis complex and to explain the pathology of cortical tuber. Methods Single-voxel PRESS 1H MRS were performed in 25 patients with clinically confirmed tuberous sclerosis complex. Region of interest included the cortical tubers and corresponding regions in the contralateral hemisphere. Then the both-side metabolites and the ratios of NAA/Cr and Cho/Cr were compared. Results Fifty single-voxel 1H MRS showed symmetric Cr peak and absence of Lac peak. The ratio of NAA/Cr (medium value 1.46±0.07; range 1.33-1.57) in 25 cortical tubers was significantly lower (t=3.024, P=0.004) than that (medium value 1.54±0.11; range 1.49-1.78 ) of normal side. However, no significant differences (t=0.339, P=0.736) were found in the mean ratio of Cho/Cr between cortical tubers (1.02±0.12) and normal side (1.00±0.15). Conclusion NAA/Cr of cortical tuber in tuberous sclerosis complex significantly decreases, but Cho is stable, as explain that possible pathological characteristics are immature neuron and/or glia. |
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