| 宋武战,汪静,池君,王莹,王喜青,王云雅.乳腺癌99Tcm-HL91乏氧显像与18F-FDG符合显像的对比研究[J].中国医学影像技术,2006,22(5):767~769 |
| 乳腺癌99Tcm-HL91乏氧显像与18F-FDG符合显像的对比研究 |
| Comparative study of 99Tcm-HL91 hypoxia imaging and 18F-FDG DHC imaging in breast cancer |
| 投稿时间：2006-01-17 修订日期：2006-03-01 |
| DOI： |
| 中文关键词: 乳腺肿瘤 放射性核素显像 99Tcm-HL91 氟脱氧葡萄糖 F18 |
| 英文关键词:Breast neoplasms Radionuclide imaging 99Tcm-HL91 Fluorodeoxyglucose F18 |
| 基金项目: |
| 作者 | 单位 | E-mail | | 宋武战 | 第四军医大学西京医院核医学科,3.老年病科,陕西 西安 710032 | | | 汪静 | 第四军医大学西京医院核医学科,3.老年病科,陕西 西安 710032 | wangjing@fmmu.edu.cn | | 池君 | 成都军区昆明总医院耳鼻喉科,云南 昆明 650032 | | | 王莹 | 成都军区昆明总医院老年病科,陕西 西安 710032 | | | 王喜青 | 第四军医大学西京医院核医学科,3.老年病科,陕西 西安 710032 | | | 王云雅 | 第四军医大学西京医院核医学科,3.老年病科,陕西 西安 710032 | |
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| 中文摘要: |
| 目的 对比研究99Tcm-HL91显像和18F-FDG显像诊断乳腺癌的临床价值。方法 31例乳腺癌患者行99Tcm-HL91和18F-FDG显像,利用计算机感兴趣区(ROI)技术计算T/NT值(病灶计数/对侧计数),定性和半定量法计算诊断灵敏度。结果 病灶摄取18F-FDG和99Tcm-HL91的 T/NT值为(3.16±0.57)、(2.14±0.36)(P<0.01);浸润性导管癌和浸润性小叶癌摄取18F-FDG T/NT值为(3.14±0.43)、(3.19±0.27)(P>0.05),摄取99Tcm-HL91 T/NT值为(2.16±0.38)、(2.10±0.32)(P>0.05);病灶T/NT值分布18F-FDG 为1.56~9.43(中位值3.15),99Tcm-HL91为1.36~6.28(中位值2.95),两者呈正相关(P<0.01);定性法18F-FDG诊断灵敏度为90%,而99Tcm-HL91为84%;半定量以T/NT值2.0为标准, 18F-FDG灵敏度为97%,以T/NT值1.5为标准, 99Tcm-HL91灵敏度为90%。结论 乳腺癌组织对18F-FDG和99Tcm-HL91均有明显的摄取,呈显著正相关;99Tcm-HL91诊断乳腺癌有较高灵敏度,具有一定临床价值。 |
| 英文摘要: |
| Objective To study and compare the diagnostic value of 99Tcm-4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime (HL91) hypoxia imaging and 18F-fluorodeoxyglucose (FDG) dual-head coincidence (DHC) imaging in primary breast cancer. Methods Thirty-one patients with primary breast cancer diagnosed by fine needle aspiration were underwent 99Tcm-HL91 and 18F-FDG tomography fusion imaging. Regions of interest (ROI) were drawn on the tumor (T) and contralateral normal breast tissue (NT), T/NT ratios were measured for all scans. The diagnostic sensitivity was measured by qualitative and semi-quantitative analysis. Results The T/NT ratio of 18F-FDG and 99Tcm-HL91 in breast cancer were (3.16±0.57), (2.14±0.36) (P<0.01); T/NT ratios of 18F-FDG in IDC (infiltrating ductal carcinoma) and ILC (infiltrating lobular carcinoma) were (3.14±0.43) and (3.19±0.27) (P>0.05), and of 99Tcm-HL91 were (2.16±0.38) and (2.10±0.32) (P>0.05). In all 31 patients T/NT ratios of 18F-FDG ranged from 1.56 to 9.43 (median: 3.15) and of 99Tcm-HL91 was 1.36-6.28 (median: 2.95). A linear correlation was found between them. The sensitivity of 18F-FDG and 99Tcm-HL91 were 90% (28/31), 84% (26/31) by qualitative analysis. Using 2.0 of T/TN as diagnostic threshold to 18F-FDG the sensitivity was 97%, and 1.5 to 99Tcm-HL91 the sensitivity was 90% in the semi-quantitative diagnosis. Conclusion The breast cancer can uptake 18F-FDG and 99Tcm-HL91 obviously, and a strong positive correlation was found between the uptake of them; 99Tcm-HL91 imaging possesses higher sensitivity and a certain clinical value in diagnosing breast cancer. |
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