| 马娜,田家玮,孙立涛.超声评价辛伐他汀对兔脑动脉粥样硬化的影响[J].中国医学影像技术,2006,22(4):551~553 |
| 超声评价辛伐他汀对兔脑动脉粥样硬化的影响 |
| Ultrasonographic evaluation on effects of simvastatin to cerebral atherosclerosis in rabbits |
| 投稿时间：2005-12-03 修订日期：2005-12-26 |
| DOI： |
| 中文关键词: 超声检查 动脉粥样硬化 兔 辛伐他汀 |
| 英文关键词:Ultrasonography Atherosclerosis Rabbits Simvastatin |
| 基金项目: |
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| 摘要点击次数: 2009 |
| 全文下载次数: 777 |
| 中文摘要: |
| 目的 探讨超声评价早期脑动脉粥样硬化的价值及辛伐他汀的治疗作用。方法 24只兔随机平均分成3组:正常对照组(A组)、高脂模型组(B组)、辛伐他汀治疗组(C组)。12周末超声分别测量颈总动脉内膜-中层厚度(IMT)、颈总动脉、椎动脉、基底动脉收缩期峰值流速(Vs)、搏动指数(PI)、阻力指数(RI)。截取动脉行病理学检查。结果 B组、C组颈总动脉IMT增厚,PI、RI增高,与A组比较差异显著,C组测值较B组减低(P<0.05)。椎动脉和基底动脉PI、RI测值组间差异显著(P<0.05),B组PI、RI较A组显著增高,C组较B组明显减低(P<0.05)。各组Vs差异均无显著性意义(P>0.05)。结论 超声检测颈总动脉结合椎、基底动脉,为诊断早期脑动脉粥样硬化提供了可靠的方法,辛伐他汀具有抗动脉粥样硬化作用。 |
| 英文摘要: |
| Objective To explore the value of ultrasonography in assessing early cerebral atherosclerosis and the effects of simvastatin. Methods Twenty-four rabbits were randomly divided into three groups: normal control group (group A), high cholesterol diet group (group B) and simvastatin group (group C). Intima-media thickness (IMT) of common carotid artery (CCA), systolic peak velocity (Vs), pulsatility index (PI) and resistant index (RI) of common carotid arteries, vertebral artery (VA) and basilar artery (BA) were detected by ultrasonography at the end of 12 weeks, respectively. Results were compared with histological examination. Results IMT, PI and RI of CCA were significantly increased in group B and group C compared with group A, and which were less severe in group C (P<0.05). PI and RI were significantly different in VA and BA among groups, which were increased in group B compared with group A and were decreased in group C compared with group B (P<0.05). While there was no significant difference in Vs (P>0.05). Conclusion Ultrasonography can provide a reliable method in assessing early cerebral atherosclerosis by detecting CCA combined with VA and BA, and simvastatin had therapeutic effects. |
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