| 吴光耀,雷皓,孙骏谟,田志雄,王川红.脑肿瘤的31P MRS特征[J].中国医学影像技术,2006,22(4):518~520 |
| 脑肿瘤的31P MRS特征 |
| 31P MRS characteristics of cerebral tumors in vivo |
| 投稿时间：2005-09-20 修订日期：2005-11-21 |
| DOI： |
| 中文关键词: 脑肿瘤 磁共振波谱学 磷脂代谢 活体 |
| 英文关键词:Brain neoplasms Magnetic resonance spectroscopy Phospholipid metabolism In vivo |
| 基金项目:国家自然科学基金资助项目(30400136);湖北省卫生厅资助课题(301140319)。 |
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| 中文摘要: |
| 目的 比较不同脑肿瘤31P MRS的变化特征,探讨31P MRS在脑肿瘤中的临床应用价值。方法 正常组36例,Ⅱ~Ⅲ级胶质瘤16例,成胶质细胞瘤12例,脑膜瘤16例。在1.5T MR机上完成波谱采集,jMRUI(1.3版)软件分析数据,计算体素内的pH值和各代谢物与β-ATP的相对浓度。结果 正常组pH 7.04±0.02,PCr/β-ATP 1.51±0.03,PCr/Pi 2.85±0.20,PDE/β-ATP 2.70±0.40,PME/β-ATP 1.01±0.03。Ⅱ~Ⅲ级胶质瘤组织碱性化,pH 7.09±0.01,与正常组比较P<0.05;PCr/β-ATP(1.50±0.04)、PCr/Pi(2.49±0.21)、PME/β-ATP(1.04±0.07)与正常组比较无显著性差异;PDE/β-ATP(1.73±0.20)显著降低,P<0.05。成胶质细胞瘤组织碱性化,pH 7.12±0.02,与正常组比较P<0.05;PCr/β-ATP(1.48±0.05)、PCr/Pi(2.39±0.23)与正常组比较无显著性差异;PDE/β-ATP(1.61±0.25)显著降低,P<0.05;PME/β-ATP(1.64±0.05)显著升高,P<0.05。脑膜瘤组织学特征是碱性化,pH 7.16±0.03,与正常组比较P<0.005;PCr和PDE显著降低,PCr/β-ATP(0.46±0.04,P<0.001)、PCr/Pi (1.08±0.16,P<0.001)、PDE/β-ATP(0.82±0.10,P<0.001)显著降低,PME/β-ATP(2.05±0.03,P<0.005)显著升高。结论 不同脑肿瘤在活体31P MRS上的变化具有特征性;31P MRS能无创性提供活体脑肿瘤pH值、能量状况及其磷脂代谢等方面的信息,有利于脑肿瘤的诊断与鉴别诊断。 |
| 英文摘要: |
| Objective To analyze feature of various cerebral tumors on 31P MRS and to explore the clinical application of 31P MRS in cerebral neoplasm. Methods The total subjects included control group (n=36), Ⅱ~Ⅲ grade gliomas (n=16), glioblastomas (n=12) and meningiomas (n=16). All data were obtained by 1.5T MR scanner, the data were analyzed with jMRUI (1.3) software, and their pH value and semi-quantitive metabolites divided by β-ATP were calculated. Results Control group: pH (7.04±0.02), PCr/β-ATP (1.51±0.03), PCr/Pi (2.85±0.20), PDE/β-ATP (2.70±0.40), PME/β-ATP (1.01±0.03). Ⅱ~Ⅲ grade gliomas: alkalosis (pH 7.09±0.01, P<0.05), PCr/β-ATP (1.50±0.04), PCr/Pi (2.49±0.21); To compare with control group, PDE/β-ATP (1.73±0.20), P<0.05. Glioblastomas: far more alkalosis, pH 7.12±0.02, P<0.05; PCr/β-ATP (1.48±0.05), PCr/Pi (2.39±0.23), PDE/β-ATP (1.61±0.25), P<0.05, significantly decreased; PME/β-ATP (1.64±0.05, P<0.05), significantly increased. Meningiomas: obvious alkalosis, pH 7.16±0.03, P<0.005; PCr and PDE significantly decreased, PCr/β-ATP (0.46±0.04, P<0.001); PCr/Pi (1.08±0.16, P<0.001); PDE/β-ATP significantly decreased, (0.82±0.10, P<0.001); PME/β-ATP increased significantly (2.05±0.03, P<0.005). Conclusion Different cerebral neoplasms demonstrate characteristic change of 31P MRS. 31P MRS is capable of providing information about cerebral tumor pH, metabolism of energy and phospholipid. It is helpful for diagnosis and differential diagnosis of brain tumor. |
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