| 王静,王新房,谢明星,吕清,黄润青,杨颖,伍静,陈欧迪.定量组织速度成像评价左旋精氨酸预适应对缺血-再灌注心肌收缩功能的影响[J].中国医学影像技术,2006,22(3):347~349 |
| 定量组织速度成像评价左旋精氨酸预适应对缺血-再灌注心肌收缩功能的影响 |
| Effects of L-arginine precondition on systolic function of acute ischemic reperfused myocardium in dogs by quantitative tissue velocity imaging |
| 投稿时间：2005-11-06 修订日期：2006-01-10 |
| DOI： |
| 中文关键词: 超声心动描记术 缺血-再灌注 预适应,L-arginine 心肌顿抑 |
| 英文关键词:Echocardiography Ischemia-reperfusion L-arginine precondition Myocardial stunning |
| 基金项目: |
|
| 摘要点击次数: 1993 |
| 全文下载次数: 680 |
| 中文摘要: |
| 目的 评价一氧化氮前体左旋精氨酸(L-arginine, L-arg)预适应对急性缺血-再灌注后局部心肌收缩功能的影响。方法 制作犬左前降支(LAD)急性闭塞60 min后再灌注120 min实验模型。19只健康杂种犬随机分为无干预组(ishcemia-reperfusion, IR组,n=12只)与L-arg组(缺血前预先经外周静脉注入L-arg溶液300 mg/kg 10 min,n=7只)。应用定量组织速度成像技术(QTVI)分别记录两组于基础状态(Bas)、缺血60 min (IS60)、再灌后R0、R60、R120时点左室前壁、下壁心肌的等容收缩期峰值速度(VIC)、收缩期峰值速度(VS)和异常收缩后收缩(PSS)的节段数。实验完成后,电镜观察危险区心肌组织的超微结构。结果 ①LAD急性闭塞后,IR组和L-arg组缺血节段的等容收缩波、收缩波明显低矮,畸变。IS60,左室前壁VIC,VS测值与基础值比较,明显降低(P<0.05~0.01);下壁VIC,VS测值则稍高于基础值(P>0.05)。IR组和L-arg组的各项观察指标间均无显著性差异(P>0.05);②恢复灌注即刻R0,二组犬的前壁VIC,VS测值较IS60稍高,但仍明显低于基础值(P<0.05~0.01); R60、R120,IR组前壁的VIC,VS测值持续减低,R120VIC,VS测值均稍低于R60(P>0.05);L-arg组前壁的VIC,VS测值则于R60,R120时点均无显著性差异;其异常PSS节段数亦少于IR组。③电镜观察结果显示L-arg组的线粒体和血管内皮损伤程度稍轻。结论 QTVI技术可准确反映心肌缺血-再灌注过程中局部心肌功能的动态变化。缺血前给予L-arg能有效改善再灌后心肌的收缩顿抑。 |
| 英文摘要: |
| Objective To observe the effects of L-arginine precondition on the regional myocardium systolic function through establishing canine model of acute ischemia-reperfusion model. Methods Nineteen mongrel dogs were randomly divided into IR group (acute occlusion left anterior descending 60 min following 120 min reperfusion) and L-arg group (iv.drop L-arginine 300 mg/kg 10 min before the occlusion). Myocardial peak velocities during isovolumetric contraction period (VIC) and ejection period (VS) in apical 2-chamber view were measured at the baseline, IS60, R0, R60, R120 by QTVI. Results ①The VIC, VS of left ventricular anterior wall (LVAW) of IS60 significant decreased compared with those of Bas after occlusion in both groups (P<0.05-0.01). The VIC, VS of LV inferior wall (LVIW) was slightly higher than Bas. There are no significant differences in the values of VIC, VS between IR group and L-arg group (P>0.05); ②The values of VIC, VS of LVAW increased at the beginning of the reperfusion compared with those of IS60, but still lower than those of Bas (P<0.05-0.01). The VIC, VS of R60, R120 in LVAW further decreased in IR group. However there is no significant difference in VIC value between R120 and R60 in L-arg group (P>0.05). Abnormal PSS of R120 was less than that in IR group (P<0.05). The systolic dysfunction in L-arg group restored earlier than that in IR group; ③The damage of endothelium cell in L-arg group was less than that in IR group. Conclusion QTVI could be used to evaluate the regional myocardial function. L-arg precondition could improve the systolic stunning of early reperfusion of the myocardium. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
