| 温朝阳,唐杰,王月香,程志刚,林倩,张高魁.血管回声跟踪技术评价动脉粥样硬化和高胆固醇血症兔模型动脉僵硬度的实验研究[J].中国医学影像技术,2006,22(2):216~218 |
| 血管回声跟踪技术评价动脉粥样硬化和高胆固醇血症兔模型动脉僵硬度的实验研究 |
| Evaluating stiffness of the artery in rabbits with atherosclerosis and hypercholesterolemia by echo-tracking technique |
| 投稿时间：2005-10-16 修订日期：2005-11-07 |
| DOI： |
| 中文关键词: 血管回声跟踪技术 兔 动脉硬化 高胆固醇血症 动脉僵硬度 |
| 英文关键词:Echo-Tracking Rabbit s Arteriosclerosis Hypercholesteremia Artery stiffness |
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| 中文摘要: |
| 目的 血管回声跟踪( ET) 技术评价动脉粥样硬化和高胆固醇血症兔腹主动脉僵硬度的研究。方法 52 只新西兰兔随机分为对照组1 、高胆固醇血症组、对照组2 和动脉粥样硬化组,以普通或高胆固醇饲养建立相应的模型。导管测量兔股动脉血压。在基础点和模型建立后,取兔左肾动脉起始部远心端约1. 5～2 cm 处的腹主动脉长轴切面, ET 技术检测动脉僵硬度。结果 动脉粥样硬化组腹主动脉弹性系数( Eρ) 和硬度指数(β) 较对照组高( P < 0. 01) ,动脉顺应性(AC) 差异无显著意义( P > 0. 05) 。高胆固醇血症组和对照组之间Eρ、β及AC 差异均无显著性意义( P > 0. 05) 。Eρ与血管舒张期内径及低密度脂蛋白(LDL-C) 呈正相关( P < 0. 05) ,β及AC 则否。Eρ、β及AC 与收缩压、舒张压、心率、血管收缩期内径、血糖( GLU) 、血清胆固醇(CH) 、血清甘油三脂( TG) 及高密度脂蛋白( HDL-C) 均不相关( P > 0. 05) 。结论 动脉粥样硬化兔模型腹主动脉僵硬度增高,高胆固醇血症兔则否。僵硬度指标中,Eρ和β敏感性较高,AC 则否。 |
| 英文摘要: |
| Objective To evaluate the stiffness of abdominal aorta in rabbits with atherosclerosis and hypercholesterolemiaby echo-tracking technique. Methods Fif ty-two rabbit s were divided into 4 groups randomly : cont rol group 1 , hypercholes-terolemia group , cont rol group 2 , and atherosclerosis group , there were 13 rabbit s in each group . The rabbit s were bredwith normal or 2 % cholesterol animal feeds according to their groups. The femoral artery blood pressure was measured withcatheter . The stiffness of abdominal aorta of every rabbit was evaluated by Echo-Tracking at the baseline and the end of thestudy. Results All the rabbits of atherosclerosis group had lipid plaques in the thoracic and abdominal aortas , and the interi-or elastic fibers board under the plagues was disrupted. Eρ(pressure-st rain elastic modulus) andβ( stiffness index) , indexesof arterial stiffness , were higher in the atherosclerosis group than those in cont rol group 2 ( P < 0. 01) , but arterial compli-ance (AC) was not ( P > 0. 05) . Eρ,βand AC were similar between hypercholesterolemia group and cont rol group 1. Eρwasrelative to diastolic diameter of artery and HDL-C positively ( P < 0. 05) , butβand AC were not . Eρ,βand AC were not rel-ative to systolic blood pressure , diastolic blood pressure , heart rate , systolic diameter of artery , blood glucose , Triglyceride( TG) , Cholesterol (CH) and HDL-C ( P > 0. 05) . Conclusion The abdominal aortas in rabbits with atherosclerosis werestiffer than normal , but that of hypercholesterinem rabbits were not . Eρ andβwere sensitive artery stiffness indexes , but AC was not . |
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