| 王家祥,方平,肖湘生,徐雪原,谭跃平.超声评价兔动脉粥样硬化病变的实验研究[J].中国医学影像技术,2006,22(2):212~215 |
| 超声评价兔动脉粥样硬化病变的实验研究 |
| Experimental study of assessing rabbit atherosclerosis with ultrasound |
| 投稿时间：2005-08-08 修订日期：2005-09-20 |
| DOI： |
| 中文关键词: 动脉粥样硬化 超声检查 动物模型 组织病理学 |
| 英文关键词:Atherosclerosis Ult rasonography Animal model Histopathology |
| 基金项目: |
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| 摘要点击次数: 2428 |
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| 中文摘要: |
| 目的 应用超声评价兔动脉粥样硬化在不同时间点主动脉壁的变化,进一步探讨超声对兔动脉粥样硬化病变的诊断价值。方法 24 只兔分别于高脂饲料饲喂前、高脂饲料饲喂8 、16 、24 周行超声和病理学检查。结果 高脂饲料饲喂前、高脂饲料饲喂后8 、16 、24 周,血流动力学参数变化无显著性统计学差异( P > 0. 05) ;随着饲喂时间延长,不同时间点超声内膜2中膜厚度( IMT) 、病理学IMT 明显增加( P < 0. 01) ;超声与病理学比较分析,兔饲喂高脂和高胆固醇饮食8 周时,超声即可显示主动脉壁的变化。结论 超声可动态准确地测量IMT ,监测AS 病变不同时间点IMT 的变化、鉴别兔动脉粥样硬化斑块内脂质和纤维成分、敏感地显示血管壁形态学的早期变化,但不能分辨斑块内微小的粥样病灶和钙化。 |
| 英文摘要: |
| Objective To study the changes of aortic wall in rabbit s atherosclerosis at different time point s and evaluateatherosclerotic lesion with ultrasound. Methods All of the 24 rabbit s were examined with ultrasound and pathology beforeand af ter feeding with high lipid and cholesterol diet for 8 , 16 , 24 weeks , respectively. Results There were no significantdifferences in hemodynamics ( P > 0. 05) before and af ter feeding with high lipid and cholesterol diet for 8 , 16 , 24 weeks.Prolonged with feeding high lipid and cholesterol diet , internal-media thick ( IMT) in ultrasound and intima-media thicknessin pathology remarkably increased (P < 0. 01) . Comparison of ultrasound feature with pathology showed that ultrasoundmight identify the changes of aortic wall after high lipid and cholesterol diet for 8 weeks. Conclusion Ult rasound can accu-rately measure IMT , and dynamically monitor the change of IMT at different time points. It also can identify the compositionof lipid and fiber , and sensitively detect early morphologic changes of vessel walls. But it can not differentiate tiny atheroma-tous lesion and calcification f rom plaque. |
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