| 张立敏,富维强,任卫东,马春燕,杨晓东.超声背向散射积分定量评价大鼠肝纤维化及肝硬化[J].中国医学影像技术,2006,22(2):209~211 |
| 超声背向散射积分定量评价大鼠肝纤维化及肝硬化 |
| Quantitative evaluation of hepatic fibrosis and cirrhosis in rats by ultrasonic integrated backscatter |
| 投稿时间：2005-09-12 修订日期：2005-10-19 |
| DOI： |
| 中文关键词: 背向散射积分 肝硬化 四氯化碳 动物,实验 |
| 英文关键词:Integrated backscatter Liver cirrhosis Carbon tet rachloride Animals , laboratory |
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| 中文摘要: |
| 目的 通过测量四氯化碳诱导的大鼠肝纤维化及肝硬化的肝脏超声背向散射积分( IBS) 并与病理对照,探讨超声背向散射积分定量评价大鼠肝纤维化、肝硬化的价值。方法 测量正常大鼠及四氯化碳作用下的大鼠肝脏近场及远场IBS 参数:平均值(AII) 及校正AII(AII%) 。同时取病理且按照病理诊断将测量结果分组为正常对照组、肝纤维化组、肝硬化组。结果 肝纤维化组AII、AII%值(27. 59 ±1. 19 ; 55. 55 ±2. 31) 、肝硬化组AII、AII%值(30. 06 ±2. 11 ; 60. 45 ±4. 17)均高于对照组(17. 80 ±1. 92 ; 36. 83 ±4. 14) ,差异显著( P < 0. 01) ;肝硬化组AII、AII%值高于肝纤维化组且有显著差异( P< 0. 01) ;各组近场及远场肝脏IBS 参数及其标化值对比无统计学意义( P > 0. 01) 。结论 超声背向散射积分技术能早期发现肝纤维化且定量评价肝纤维化、肝硬化。 |
| 英文摘要: |
| Objective To discuss the quantitative assessment of hepatic fibrosis and cirrhosis of rat s induced by CCl4 usingult rasonic integrated backscatter ( IBS) and compare with pathological features. Methods Liver’s IBS parameters of normalrat s and those of injected CCl4 were measured by AII and AII%. All data were divided into three groups according to thepathologic standard : cont rol group , hepatic fibrosis group and cirrhosis group . Results AII and AII% of case group werehigher than those of cont rol groups ( P < 0. 01) . AII and AII% of cirrhosis group were higher than those of hepatic fibrosisgroup ( P < 0. 01) . Conclusion Ult rasonic IBS can detect hepatic fibrosis early , which is able to quantitatively evaluate he-patic fibrosis and cirrhosis. |
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