| 张明,王渊,刘海,章士正,鱼博浪,陈燕,王微微.小脑参与痛觉调节的fMRI研究[J].中国医学影像技术,2006,22(1):27~30 |
| 小脑参与痛觉调节的fMRI研究 |
| Cerebellar pain modulation : functional MRI study |
| 投稿时间：2005-08-08 修订日期：2005-10-29 |
| DOI： |
| 中文关键词: 磁共振成像,功能性 电刺激 痛觉 小脑 |
| 英文关键词:Magnetic resonance imaging, functional Elect rical stimulation Pain Cerebellum |
| 基金项目: |
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| 中文摘要: |
| 目的 利用功能磁共振成像技术(fMRI) 观察小脑各亚区在不同强度电刺激时的激活反应,探讨小脑对于痛觉调控的作用。方法 对10 名右利手健康志愿者分别施加1 倍痛阈、3 倍痛阈两个不同强度的电刺激任务,同期进行全脑fMRI 扫描,应用功能性神经图像分析(AFNI) 软件包进行后处理以显示小脑激活的变化。结果 非伤害性电刺激(1 倍痛阈强度) 主要激活对侧小脑半球小叶Ⅵ、Ⅶ区和同侧小脑半球Ⅶ、Ⅷ区,以同侧半球的BOLD 信号较强;伤害性电刺激(3 倍痛阈强度) 诱发的激活区主要位于同侧小脑半球小叶Ⅲ～ Ⅵ区,对侧小脑半球Ⅵ区,前蚓部,蚓旁区和深部小脑核团的一部分(顶核和齿状核) ,其中仍以同侧激活区范围较大,信号亦明显强于对侧。结论 高强度痛觉电刺激额外激活同侧小脑半球小叶Ⅲ～ Ⅵ区,前蚓部,蚓旁区和深部小脑核团,这些脑区应该属于小脑伤害感受性环路的一部分,它们可能在全身痛觉调控网络中更为重要。 |
| 英文摘要: |
| Objective To observe activated changes of cerebellar subregions induced by elect rical stimulation of different in-tensity in function magnetic resonance imaging (fMRI) and discuss the effect of these areas in pain modulation. Methods Ten healthy right2handed volunteers were performed respectively with different elect rical stimulation of 1,3 times pain threshold intensity. The whole2brain fMRI scanning was implemented at the same time. All data were postprocessed bymeans of analysis of functional neuroimages (AFNI) to reveal the regional activated changes of cerebellum. Results The ac-tivation elicited by non-noxious elect rical stimulation mainly located in the cont ralateral cerebellar hemispheric lobule Ⅵ, Ⅶ and ipsilateral lobule Ⅶ, Ⅷ, the BOLD signal of ip silateral hemisphere showed relatively significant ; When applying noxiouselect rical stimulation , the ipsilateral cerebellar hemispheric lobule Ⅲ- Ⅵ, cont ralateral lobule Ⅵ, anterior vermis , paraver-mis area and part of the deep cerebellar nuclei (dentate nucleus and fastigial nucleus) were activated simultaneously , the acti-vation response of ipsilateral cerebellar hemisphere still displayed more st rongly with larger activated region than cont ralater-al hemisphere. Conclusion In cont rast to non-noxious elect rical stimulation , noxious stimulation additionally revealed activa-tion in the ipsilateral cerebellar hemispheric lobule Ⅲ- Ⅵ, anterior vermis , paravermis area and part of the deep cerebellar nuclei , these areas ought to belong to the part of cerebellar nociceptive circuit s and may be more important in body pain mod-ulation network. |
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