| 伍建林,张清,张竞文,宋清伟,苗延巍.愉快及非愉快气体激活相应脑区的功能磁共振成像实验研究[J].中国医学影像技术,2006,22(1):2~6 |
| 愉快及非愉快气体激活相应脑区的功能磁共振成像实验研究 |
| Functional MRI study on regional brain responses to pleasantand unpleasant odors |
| 投稿时间：2005-09-05 修订日期：2005-10-27 |
| DOI： |
| 中文关键词: 磁共振成像,功能性 嗅觉 半球优势,大脑 情绪 |
| 英文关键词:Magnetic resonance imaging, functional Smell Dominance,cerebral Mood |
| 基金项目:本课题受国家自然科学基金资助(30470515) . |
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| 中文摘要: |
| 目的 采用功能磁共振成像(fMRI) 观察和研究愉快及非愉快气体激活相应脑区的情况并对嗅觉中枢及其通路进行功能定位。方法 12 名右利手、无嗅觉障碍健康志愿者参加实验。采用乙酸戊酯为愉快刺激气体,吡啶为非愉快气体,组块设计,1. 5T MRI 行EPI 序列扫描,用Matlab 5. 3 及SPM 99 、Talairach 等软件数据后处理。结果 愉快及非愉快气体刺激海马回钩、丘脑内侧背核、眶额回皮质均出现明显激活,两种气味均表现为右侧大脑半球优势激活,即右侧额叶上、中、下回、右侧眶额回、右侧海马回钩以及右侧丘脑背内侧核均较左侧半球相应脑区激活明显;与情绪相关脑区亦发现激活,即额内侧回、海马旁回、扣带回、颞上回以及右侧额叶上、中、下回。愉快气体激活大脑前区为主,非愉快气体激活大脑后区明显。结论 BOLD2fMRI 是研究人类嗅觉功能的有效方法。本研究进一步验证了海马回钩、丘脑内侧背核和眶额回为嗅觉中枢及其重要通路,并且右侧大脑半球为嗅觉“优势半球”;气味嗅觉还引起与情绪相关脑区的激活,并且愉快情绪主要与大脑前部区域有关,不愉快情绪主要与大脑后部区域关系密切。 |
| 英文摘要: |
| Objective To identify regional activation of the human cerebral cortex in response to pleasant and unpleasantodors with functional MRI(fMRI),and to localize the olfactory centers and pathways. Methods Twelve right2handedhealthy volunteers were recruited in this study. Two kinds of odors were given to them through the personally developed in2st rument . One was amyl acetate ,which was regarded as pleasant odor , and the unpleasant one was pyridine. Block designwas adopted in this experiment ,and EPI wasperformed on 1.5TMRI,the raw fMRI data were processed with Matlab 5.3 ,SPM 99 and Talairach tool sof twares. Results Activation was present in the olfactory centers and important pathways dur2ing administ ration of pleasant and unpleasantodors, such as uncus of hippocampus, lateral medial nucleus of thalamus andorbitof rontal gyru. Both the two odors had more activation in the right hemisphere than the lef t.For example ,the superior ,middle ,inferior gyrus of right frontal lobe, right orbitof rontal gyrus, right uncus of hippocampus and right lateral medialnucleus of thalamus were activated more prominently than the cont ralateral corresponding region. The mood related regionswere also found to be activated,including medial f rontal gyrus,parahippocampal gyrus,cingulate gyrus, superior temporalgyrus and the superior,middle,inferior gyrus of right frontallobe. Further,it was found that the anterior part of the cere2brum was activated by the pleasant odor and that a more posterior part was activated by the unpleasant odor.Conclusion BOLD2fMRI is an useful method for studying of human olfactory system. The uncus of hippocampus, lateral medial nucleusof thalamus and orbitof rontal gyrus are further proved the olfactory centers and important pathways,and presented dominantin the right hemisphere. In the same time,odors can activate the mood related regions. The pleasant feeling is mainly con2cerned with the anterior part of the cerebrum,while the unpleasant feeling is involved in the posterior part of the cerebrum. |
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