| 贾秀川,刘怀军,吕红艳.兔局灶性脑缺血/再灌注损伤后脑水肿的系列MRI动态演变[J].中国医学影像技术,2005,21(11):1671~1673 |
| 兔局灶性脑缺血/再灌注损伤后脑水肿的系列MRI动态演变 |
| Dynamic changes of cerebral edema explored by serial MRI in focal cerebral ischemia/reperfusion model of rabbits |
| 投稿时间：2005-06-22 修订日期：2005-08-10 |
| DOI： |
| 中文关键词: 缺血/再灌注 脑水肿 兔 |
| 英文关键词:Ischemia/reperfusion Cerebral edema Rabbit |
| 基金项目:卫生部999中药注射液科研基金资助项目(200310)。 |
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| 中文摘要: |
| 目的 研究兔局灶性脑缺血/再灌注损伤后脑水肿的系列MRI动态演变。方法 健康新西兰白兔27只,随机分为两组:A组5只,为假手术组;B组22只,为线栓法局灶性脑缺血/再灌注模型组。于缺血3 h/再灌注后1 h(4只)、3 h、6 h、12 h、1天、3天、7天(各3只)行头颅MR 扫描,扫描序列包括T1WI、T2WI、液体衰减反转恢复(FLAIR)、弥散加权成像(DWI)及强化后T1WI扫描,观察缺血再灌注后脑组织T2WI、DWI及强化后T1WI信号参数的改变。结果 |
| 英文摘要: |
| Objective To explore the dynamic changes of cerebral edema by serial MRI in focal cerebral ischemia/reperfusion model of rabbit. Methods Twenty-seven New Zealand white rabbits were randomly divided into two groups: Group A (n=5) was sham-operated. In group B (n=22), the focal cerebral ischemia/reperfusion model was made. MRI was performed 1 h (n=4), 3 h, 6 h, 12 h, 1 day, 3 days, and 7 days (n=3), respectively after reperfusion, the sequences including T1WI, T2WI, fluid-attenuated inversion recovery, diffusion-weighted imaging and post-contrast T1WI. The signal changes of T2WI, diffusion-weighted imaging and post-contrast T1WI were observed. Results MRI showed the abnormal signal in left temporal, parietal lobe and basal ganglia. The signal on T2WI increased in 1 day, and then declined, but the change of apparent diffusion coefficient was on the contrary. Conclusion The appearance of cerebral edema after reperfusion was the effect of both vasogenic and cytotoxic edema. And the vasogenic edema was associated closely with blood-brain barrier disruption. |
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