| 张峰,国贵臣,徐宏,李康安,赵京龙,李玉洁,张贵祥,古宏晨.SPIO增强MRI对兔肝脏微小肿瘤检出的研究[J].中国医学影像技术,2005,21(11):1648~1651 |
| SPIO增强MRI对兔肝脏微小肿瘤检出的研究 |
| SPIO-enhanced MRI evaluation of rabbit bearing VX2 micro-hepatoma |
| 投稿时间：2005-07-30 修订日期：2005-09-08 |
| DOI： |
| 中文关键词: 超顺磁性氧化铁 动物,实验 VX2肿瘤 磁共振成像 |
| 英文关键词:Superparamagnetic iron oxide Animals, laboratory VX2 tumor Magnetic resonance imaging |
| 基金项目:本课题受国家自然科学基金资助(30170286)。 |
|
| 摘要点击次数: 2571 |
| 全文下载次数: 1075 |
| 中文摘要: |
| 目的 探讨超顺磁性氧化铁(SPIO)增强MR不同序列成像对兔VX2肝微小肿瘤病灶的检出率。方法 15只新西兰大白兔肝内种植VX2肿瘤，分别在种植肿瘤后7天、14天行MRSET1WI、FSET2WI、GRET2WI、GRET1WI平扫和SPIO增强扫描，记录不同检查序列所显示的肿瘤数目比较显示率，确定SPIO增强MRI最佳扫描参数。结果 15只兔肝内种植VX2肿瘤后共有15个肿瘤生长成功率100％。种植后7天肿瘤<5mm> SPIO增强序列GRET2WI、GRET1 |
| 英文摘要: |
| Objective To investigate the value of superparamagnetic iron oxide (SPIO) enhanced MRI with different sequences in detection of rabbit bearing VX2 micro-hepatoma. Methods Plain and SPIO-enhanced MRI were performed for all rabbits bearing VX2 tumor in the liver with the sequences of SE T1WI, FSE T2WI, GRE T2*WI and GRE T1WI. Micro-hepatoma was determined at different sequences and the tumor detectability was statistically analyzed respectively. Results Fifteen tumors grew from 3 mm to 5 mm in diameter with success rate of 100% at 7 days after the implantation. Total 15 tumors were depicted by GRE T2*WI and GRE T1WI. There was markedly statistical difference (P<0.01) compared with other sequences. Fourteen days later, tumors grew to 1-2 cm in diameter. Apart from GRE T2*WI without SPIO enhancement, the rest of imaging modality had the same detectability of tumors (P>0.05). Conclusion SPIO-enhanced MRI can significantly increase the detectability of VX2 micro-tumors in rabbit livers and GRE T2*WI is the best sequence in depicting hepatic micro-tumors. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
