| 张贵祥,赵京龙,李玉洁,李康安,张峰,周根泉,张悦萍.分子影像学的研究范畴及其进展[J].中国医学影像技术,2005,21(11):1636~1639 |
| 分子影像学的研究范畴及其进展 |
| Research category and progress of molecular imaging |
| 投稿时间：2005-07-29 修订日期：2005-08-30 |
| DOI： |
| 中文关键词: 分子影像学 细胞 信号 磁共振成像 体层摄影术,发射型计算机 体层摄影术,X线计算机 分子探针 |
| 英文关键词:Molecular imaging Cell Signal Magnetic resonance imaging Tomography, emission-computed Tomography, X-ray computed Molecular probes |
| 基金项目: |
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| 摘要点击次数: 2010 |
| 全文下载次数: 1287 |
| 中文摘要: |
| 分子影像学的成像基础是生物体的细胞,都含有水、无机盐、离子和碳水化合物或有机小分子等小分子物质和蛋白质、糖类、脂类、核酸等大分子物质。机体内直接调节细胞生命活动的信息分子分为三种:局部化学介质、激素和神经递质。实现真正意义上的分子影像学技术的三大要素为分子探针、信号放大和高灵敏探测仪。分子影像学利用分子探针→插入人体细胞内→遇到特定基因产物或特定分子时→发射信号→PET、MRI、CT、光学成像仪或红外线记录其信号→显示其分子图像、代谢图像、基因转变图像。 |
| 英文摘要: |
| The foundation of molecular imaging is cells, because they contain micromolecules of water, inorganic salt, iron, carbohydrate and macromelecules of organism such as protein, saccharide, lipid, and nucleic acid. Vital movement of living cell is regulated by three kinds of information molecules including chemical mediator, hormone and neurotransmitter. There are three main molecular imaging techniques: molecular probes, signal amplifications and supersensitive survey meters. Metabolic map and gene conversion are based on molecular probe → insert living cells → meet special elements or gene products → transmit signals → PET, MRI, CT, optical formatter or ultra-red ray machine → display real molecular imaging. |
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