| 张晖,武金玉,高文,严昆,王艳滨,杨薇,尹珊珊,陈敏华.肝转移癌射频消融疗效及与化疗关系探讨:附134例分析[J].中国医学影像技术,2005,21(9):1404~1406 |
| 肝转移癌射频消融疗效及与化疗关系探讨:附134例分析 |
| Efficacy of radiofrequency ablation combined with chemotherapy: results in 134 cases of liver metastases |
| 投稿时间：2005-05-17 修订日期：2005-07-08 |
| DOI： |
| 中文关键词: 超声检查 射频消融 肝转移癌 化疗 |
| 英文关键词:Ultrasonography Radiofrequency ablation Hepatic metastases Chemotherapy |
| 基金项目:首都医学发展科研基金重点学科基金资助(ZD 199909);北京大学医学部"十五"、"211工程"重点学科建设项目资助(523);北京市重大项目培育专项基金资助(Z0005190040431)。 |
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| 中文摘要: |
| 目的 评价经皮射频消融(RFA)结合化疗对肝脏转移性肿瘤(MLC)的疗效。方法 134例336个MLC经皮射频消融治疗,根据接受化疗情况分为:RFA组40例,RFA前化疗组52例,RFA后化疗组8例,RFA前后全化疗组34例。结果 灭活率为95.8%,11.6%病灶局部复发增大;前化疗组复发病灶率(6.3%)与后化疗组(23.5%)及全化疗组(19.1%)有显著差异(P＜0.01)。本组病例中位生存时间为(21.0±2.2)个月。结论 RFA微创治疗MLC局部灭活率高,并可对再发或复发病例反复多次治疗而有效延长患者生存期,并具有并发症少、患者生存质量高的优势;本组病例显示RFA治疗MLC有良好的应用前景。 |
| 英文摘要: |
| Objective To investigate the efficacy of radiofrequency ablation (RFA) and chemotherapy in metastatic liver carcinomas (MLC). Methods The treatment Results of 134 patients with 336 MLCs by ultrasound-guided RFA were retrospectively analyzed. The 134 patients were divided into 4 groups according to chemotherapy condition: 40 patients underwent RFA treatment alone (Ⅰ group); 52 patients received RFA and systematic chemotherapy before RFA (Ⅱ group); 8 patients received RFA and systematic chemotherapy after RFA (Ⅲ group); the rest 34 patients had RFA and chemotherapy before and after RFA (Ⅳ group). Results In the 134 patients, the tumor necrosis rate was 95.8% and local recurrence was found in 39 tumors (11.6%) 2-19 months after RFA treatment. There was significant difference in local recurrence rate between Ⅱ group and Ⅳ group. The medial overall survival was (21.0±2.2) months. Conclusion RFA could effectively ablate MLC and could be safely repeated for recurrences or new tumors; therefore benefit the patient's survival. It will play increasing important role in treating MLC. |
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