| 于春水,林富春,李坤成,蒋田仔,朱朝喆,秦文,陈彪.脊髓型多发性硬化脑灰质弥散张量成像研究[J].中国医学影像技术,2005,21(9):1364~1367 |
| 脊髓型多发性硬化脑灰质弥散张量成像研究 |
| Study on the brain gray matter in spinal form of multiple sclerosisusing diffusion tensor imaging |
| 投稿时间：2005-05-09 修订日期：2005-07-15 |
| DOI： |
| 中文关键词: 脊髓型多发性硬化 脑灰质 弥散张量成像 直方图分析 |
| 英文关键词:Spinal form of multiple sclerosis Brain gray matter Diffusion tensor imaging Histogram analysis |
| 基金项目:本课题为北京市优秀人才培养专项资助经费资助项目。 |
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| 中文摘要: |
| 目的 运用DTI 直方图分析,研究脊髓型多发性硬化(SMS) 患者是否存在脑灰质异常及脑灰质DTI 指标与临床评分的相关性。方法 对25 例SMS 患者和35 例正常志愿者行常规MRI 和DTI 检查,分割提取脑灰质后,研究SMS 患者脑灰质平均弥散率(MD) 和分数各向异性( FA) 直方图的异常变化。结果 OSMS 患者脑灰质体积明显小于正常志愿者( P < 0. 001) 。OSMS 患者脑灰质MD 和FA 直方图指标与正常志愿者间存在显著差异( P < 0. 01) 。在OSMS 患者,所有脑灰质DTI 直方图指标与扩展残疾状态评分( EDSS) 均无相关性,但锥体束和感觉系统( PSS) 评分与脑灰质平均MD ( r =0. 54 , P = 0. 005) 和MD 直方图峰高( r = - 0. 41 , P = 0. 04) 中度相关。结论 OSMS 患者脑灰质存在明显萎缩和弥散异常,这可能与继发于脊髓病变的逆行性脑灰质神经元变性有关。 |
| 英文摘要: |
| Objective To investigate whether patients with spinal form of multiple sclerosis (SMS) have brain gray matter( GM) damage by using diffusion tensor imaging (DTI) histogram analysis , and whether DTI-derived measures of the graymatter correlate with clinical scores. Methods Conventional and DTI scans were obtained from 25 patients with SMS and 35cont rol subject s. Af ter segmentation of the brain GM , The abnormal changes of the mean diffusivity (MD) and f ractionalanisot ropy ( FA) histograms of the GM were studied. Results The average GM volume of patients with SMS was significantly lower than that of cont rols ( P < 0. 001) . All the MD and FA histogram-derived measures of the GM were significantlydifferent between patients with SMS and controls ( P < 0. 01) . In patients with SMS , none of the considered measures correlated with Expanded Disability Status Scale ( EDSS) scores. However , the pyramidal and sensory system (PSS) scores correlated with the average MD ( r = 0. 54 , P = 0. 005) and MD peak height ( r = - 0. 41 , P = 0. 04) of the NAGM. Conclusion The brain GM of patients with SMS had at rophy and occult damage , which probably caused by a ret rograde degenerationof neurons secondary to spinal cord damage. |
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