| 盛希忠,刘作勤,赵成如,孔令斌,孟建文,朱肖杰,李晓卫,武乐斌,唐军,王勤,王传栋,刘文广.温度敏感型液体栓塞剂治疗脑动静脉畸形的实验研究[J].中国医学影像技术,2005,21(9):1353~1355 |
| 温度敏感型液体栓塞剂治疗脑动静脉畸形的实验研究 |
| Thermosensitive liquid embolic agent for the treatment of cerebral arteriovenous malformations: an experimental study |
| 投稿时间：2005-06-24 修订日期：2005-08-31 |
| DOI： |
| 中文关键词: 栓塞剂,温度敏感性 动静脉畸形 |
| 英文关键词:Embolic agent, thermosensitive Arteriovenous malformation |
| 基金项目:国家高技术研究发展计划(863计划)项目(2002AA326100)。 |
| 作者 | 单位 | E-mail | | 盛希忠 | 山东大学医学院,山东 济南 250012 | | | 刘作勤 | 山东省医学影像学研究所,山东 济南 250021 | liuzuoqin666@sina.com | | 赵成如 | 山东省医疗器械研究所,山东 济南 250100 | | | 孔令斌 | 山东省医疗器械研究所,山东 济南 250100 | | | 孟建文 | 山东省医疗器械研究所,山东 济南 250100 | | | 朱肖杰 | 山东省医疗器械研究所,山东 济南 250100 | | | 李晓卫 | 天津大学高分子研究所,天津 300072 | | | 武乐斌 | 山东省医学影像学研究所,山东 济南 250021 | | | 唐军 | 山东省医学影像学研究所,山东 济南 250021 | | | 王勤 | 山东省医疗器械研究所,山东 济南 250100 | | | 王传栋 | 山东省医疗器械研究所,山东 济南 250100 | | | 刘文广 | 天津大学高分子研究所,天津 300072 | |
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| 中文摘要: |
| 目的 应用聚氮-异丙基丙烯酰胺(PNIPAM)栓塞猪的颅底微血管网(RMB),探讨其栓塞脑动静脉畸形(AVM)的可行性。方法 栓塞36头猪的RMB,血管造影随访栓塞效果。组织学检查,观察栓塞血管及其周围改变。结果 对36头家猪的RMB进行栓塞,栓塞后34头动物存活良好。复查造影24头,21头未出现RMB血管再通。组织学见栓塞剂在血管内可弥散到直径为100~200 μm的血管腔内。急性期,微血管腔内共聚物周围可见中性粒细胞,内膜完整,无剥脱和坏死。亚急性期和慢性期,微血管腔内仍可见共聚物存在,可见散在的单核细胞和嗜酸性粒细胞。肌层松散,大部分细胞核降解,呈缺血样改变。结论 PNIPAM对AVM模型栓塞稳定,生物相容性好,不透X线,不粘管,可作为脑AVM血管内治疗的一种新型液体栓塞材料。 |
| 英文摘要: |
| Objective To embolize swine rete mirabile (RMB) with poly (N-isopropylacrylamide) (PNIPAM) and investigate its embolic feasibility as an embolic agent in cerebral arteriovenous malformations (AVMs). Methods RMB embolization was performed in 36 swine. Follow-up angiography was performed for embolic efficacy. Embolized RMBs were examined histopathologically and the alterations of inside RMB and surrounding tissue were observed. Results RMB embolization was performed in 36 swine, 34 swine survived after the embolization. Follow-up angiography was performed in 24 swine, there was no RMB recanalization in 21 swine. Histopathologically, the copolymer was found diffused in vessels of 100~200 μm in diameter. In acute group, neutrophilic granulocytes scattered surrounding the copolymer, endothelial integrity was observed, without endothelial denuding and necrosis. In subacute and chronic groups, the copolymer was still found inside RMBs, scattered mononuclear cells and eosinocytes were found inside and surrounding it. The muscular layer was loosened like ischemia, with most muscular nuclei degraded. Conclusion As a thermosensitive embolic material, the PNIPAM has optimized characteristics including embolic instability, better biocompatibility, radiopacity and non-adhesiveness, could be regarded as a new liquid embolic material in endovascular treatment of cerebral AVMs. |
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