| 夏爽,祁吉,尹建忠,薛永刚.单侧感音神经性耳聋病人听觉中枢的fMRI研究[J].中国医学影像技术,2005,21(9):1312~1316 |
| 单侧感音神经性耳聋病人听觉中枢的fMRI研究 |
| Functional MRI study of auditory cortex in patientswith unilateral sensorineural hearing loss |
| 投稿时间：2005-07-10 修订日期：2005-08-02 |
| DOI： |
| 中文关键词: 感音神经性耳聋 听皮质 磁共振成像,功能性 半球优势 频率敏感性空间排列结构 |
| 英文关键词:Sensorineural hearing loss Auditory cortex Magnetic resonance imaging , functional Lateralization Tono-topicity |
| 基金项目:天津市卫生局科研课题(99 KY004) 。 |
|
| 摘要点击次数: 2878 |
| 全文下载次数: 1162 |
| 中文摘要: |
| 目的 探讨单侧感音神经性耳聋病人与正常听力者的听皮质频率敏感性排列结构的差异;双侧听皮质中枢半球优势的变化;单侧感音神经性耳聋病人皮层下区听觉传导通路的变化。方法 20 例正常志愿者和20 例单侧感音神经性耳聋病人,分别采集T1WI、GRE2EPI 及3D GRE T1WI 影像。采用组块式方法分别随机给予500 Hz ,4000 Hz 两种纯音刺激,每种刺激重复2 次。所有图像均经AFNI 进行后处理,统计阈值概率设定为P < 10 - 5 ,激活范围阈值设定为半径5 mm ,体积300 mm3 的连续激活区域考虑为有意义激活区。结果 正常听力者和单侧耳聋病人给予单耳500 Hz ,4000 Hz 刺激时,二者对于听皮质激活容积存在统计学差异( P < 0. 05) 。正常听力者给予单耳刺激表现为对侧半球优势,半球激活容积比分别为7. 56 ,6. 02 (右耳刺激) ;2. 56 ,5. 11 (左耳刺激) 。而单侧耳聋病人则表现为同侧半球优势,半球激活容积比分别为0. 62 ,0. 69 (左侧耳聋,右耳刺激) ;0. 96 ,0. 83 (右侧耳聋,左耳刺激) 。结论 正常听力者对500 Hz 和4000 Hz 的频率刺激激活区的位置存在差别。单侧感音神经性耳聋失去了听觉中枢的频率敏感性空间排列结构。单侧耳聋病人表现为同侧半球优势。500 Hz 对正常听力者和单侧感音神经性耳聋病人的听皮质激活范围明显大于4000 Hz 者。 |
| 英文摘要: |
| Objective To study the difference of tonotopicity between hearing and unilateral hearing loss patient s , and toreveal the lateralization of functional auditory cortex between hearing and hearing-loss patients. Methods Twenty hearingsubjects and 20 unilateral (10 lef t , 10 right) hearing-loss patient s received anatomical T1WI , GRE-EPI fMRI with a 1. 5 Twhole body MRI scanner and high-resolution 3D GRE T1WI. Experimental tasks included randomly pure-sound of 500 Hz ,4000 Hz stimulating. Following block design , 4 t rial blocks and 5 cont rast blocks were performed alternatively. Realigning ,normalizing and smoothing were performed using AFNI for fMRI data , activation foci were superposed on high-resolutionT1WI. Numbers of activative volumes were included when statistical threshold P < 10 - 5 , 5 mm radius and 300 mm3 continuous stimulating areas. Results There was statistically difference between 500 Hz and 4000 Hz ( P < 0. 05) in both hearingand unilateral hearing-loss patients. The latter was smaller that the former. It showed cont ralateralization in hearing subjectswhen given singleear stimulation of 500 Hz and 4000 Hz. The ratio of hemisphere stimulating volume was 7. 56 , 6. 02 ( rightstimulation) ; 2. 56 , 5. 11 (lef t stimulation) . But the unilateral hearing-loss patient s showed ipsilateralization when given singleear stimulation of 500Hz and 4000Hz . The ratio of hemisphere stimulating volume was 0. 62 , 0. 69 ( right stimulation) ;0. 96 , 0. 83 (lef t stimulation) . Conclusion It showed tonotopicity in hearing subject s and the stimulating area of 500 Hz located in the anterior part of the Heschl’s gyrus , the stimulating area of 4000 Hz were in the posterior-lateral part . But the unilateral hearing-loss patients lost their tonotopicity when given different f requency stimulation. The hearing subjects showedcont ralateralization and the unilateral hearing-loss patient s showed ipsilateralization. The extent of stimulating area of 500 Hzis obviously larger than that of 4000 Hz. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
