| 于春水,林富春,李坤成,蒋田仔,朱朝喆,秦文,陈彪.复发好转型多发性硬化磁化传递成像研究[J].中国医学影像技术,2005,21(8):1202~1204 |
| 复发好转型多发性硬化磁化传递成像研究 |
| Study of relapsing-remitting multiple sclerosis by using magnetization transfer imaging |
| 投稿时间：2005-05-09 修订日期：2005-07-15 |
| DOI： |
| 中文关键词: 多发性硬化 磁化传递成像 直方图分析 |
| 英文关键词:Multiple sclerosis Magnetization transfer imaging Histogram analysis |
| 基金项目:本课题为北京市自然科学基金资助项目(7042026)。 |
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| 中文摘要: |
| 目的 利用磁化传递率(MTR)直方图分析,研究复发好转型多发性硬化(RRMS)脑异常改变及MTR直方图指标与扩展残疾状态 (EDSS)评分的相关性。方法 对29例RRMS患者和35例正常志愿者行T2WI和磁化传递成像检查,计算出每个体素的MTR值后,绘制出全脑MTR直方图并对其进行分析。结果 RRMS患者的全脑MTR直方图明显左移,峰高降低。RRMS患者的全脑平均MTR 明显低于正常志愿者 (P=0.025),MTR直方图峰位置 也明显低于正常志愿者 (P=0.022)。在RRMS患者,全脑MTR直方图峰高与EDSS评分中度相关 (r=-0.411, P=0.027)。结论 脑MTR直方图分析可显示RRMS患者脑异常改变,脑MTR直方图峰高可用于监测该病的临床进展。 |
| 英文摘要: |
| Objective To investigate the abnormal changes in the brain in patients with relapsing-remitting multiple sclerosis (RRMS) by using magnetization transfer ratio (MTR) histogram analysis, and to determine whether MTR histogram measures correlate with expanded disability status scale (EDSS) scores. Methods Conventional and magnetization transfer imaging scans were performed in 29 patients with RRMS and 35 controls. After the MTR of each voxel was calculated, MTR histograms were generated and analyzed. Results In contrast to control subjects, the average MTR histogram of RRMS patients shifted to left with a lower peak height. The average MTR of patients with RRMS ( %) was significantly lower than that ( %) of control subjects (P=0.025), and the MTR histogram peak location ( %) was also significantly lower than that ( %) of control subjects (P=0.022). In patients with RRMS, the MTR histogram peak height moderately correlated with EDSS scores (r=-0.411, P=0.027). Conclusion MTR histogram analysis showed abnormal changes in the brain in patients with RRMS, and the MTR histogram peak height can be used to monitor the progress of this disease. |
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