| 万娅敏,高剑波,王振豫,杨学华,陈学军,周志刚,郭华.脑星形细胞瘤增强MR表现与MMP-9表达、血管形成的关系[J].中国医学影像技术,2005,21(8):1190~1192 |
| 脑星形细胞瘤增强MR表现与MMP-9表达、血管形成的关系 |
| Correlation of contrast enhanced MR image with expression of matrix metalloproteinase-9 and angiogenesis in astrocytoma |
| 投稿时间：2005-02-18 修订日期：2005-06-01 |
| DOI： |
| 中文关键词: 星形细胞瘤 明胶酶 B 磁共振成像 |
| 英文关键词:Astrocytoma Gelatinase B Magnetic resonance imaging |
| 基金项目: |
|
| 摘要点击次数: 1540 |
| 全文下载次数: 955 |
| 中文摘要: |
| 目的 探讨星形细胞瘤MR强化与基质金属蛋白酶-9 (MMP-9)表达、血管形成及病理分级的关系。方法 采用免疫组织化学(S-P)法,用抗MMP-9抗体及抗CD34单抗对 40例星形细胞瘤组织标本进行标记分析,并测定MR图像上肿瘤的强化程度。结果 星形细胞瘤的强化越明显,MMP-9表达越高,血管形成也越明显(P<0.05);随着星形细胞瘤级别的增高,MMP-9、CD34的表达越高(P<0.05)。结论 星形细胞瘤的强化程度与MMP-9的表达及血管形成密切相关。 |
| 英文摘要: |
| Objective To investigate the correlation of MR signs of contrast enhancement with the expression of matrix metalloproteinase-9, angiogenesis and the pathologic grades in astrocytomas. Methods The MMP-9 and MVD expression were detected in 40 cases of astrocytomas by immunohistochemical staining using monoclonal antibody to MMP-9 and CD34. The extent of contrast enhancement was determined on MR. Results The extent of contrast enhancement in gradeⅠ-Ⅱ astrocytoma was significantly lower than that in gradeⅢ-Ⅳ astrocytoma (P<0.05); the larger contrast enhancement extent was the higher the expression of MMP-9 and MVD would be (P<0.05); MVD and expression of MMP-9 in gradeⅠ-Ⅱ astrocytoma was significantly lower than that in grade Ⅲ-Ⅳ astrocytoma (P<0.05). Conclusion The extent of contrast enhancement in astrocytomas has a close correlation with the expression of MMP 9 and angiogenesis and the pathologic grades. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
