| 郑奎宏,马林,郭勇,郭行高,梁丽.多发性硬化颈髓扩散张量成像的初步研究[J].中国医学影像技术,2005,21(5):703~706 |
| 多发性硬化颈髓扩散张量成像的初步研究 |
| Diffusion tensor MRI of the cervical spinal cord in multiple sclerosis |
| 投稿时间：2004-09-06 修订日期：2005-02-28 |
| DOI： |
| 中文关键词: 脊髓 多发性硬化 磁共振成像 扩散 |
| 英文关键词:Spinal cord Multiple sclerosis Magnetic resonance imaging Diffusion |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨多发性硬化颈髓的扩散张量成像(diffusion tensor imaging, DTI)的可行性及临床应用价值。方法 采用平面回波成像技术对36例健康志愿者和12例多发性硬化患者行颈髓的扩散张量成像检查,并测量其表观扩散系数(apparent diffusion coefficient, ADC)值、各向异性分数(fractional anisotropy, FA)值、第1本征值(λ1)、第2本征值(λ2)及第3本征值(λ3)。结果 ADC图与FA图均能显示多发性硬化患者颈髓之异常信号区,其ADC值为(1473.7±227.8)×10-6mm2/s,FA值为(467.83±43.66)×10-3,λ1值为(2024.1±283.3)×10-6mm2/s,λ2值为(1151.8±146.1)×10-6mm2/s,λ3值为(1231.0±360.9)×10-6mm2/s,2λ1/(λ2＋λ3)值为1.73±0.22。多发性硬化患者颈髓病变区的ADC、λ1 、λ2、λ3值明显高于正常组(P＜0.05),其FA值与2λ1/(λ2＋λ3)值明显低于正常组(P＜0.05),λ1与λ2、λ3值之间有显著性差异(P＜0.05),λ1大于λ2与λ3。结论 DTI是一种显示颈髓多发性硬化的可靠检查手段,其病变区各向同性扩散明显增高,其各向异性扩散明显减低;颈髓病变区仍保持了各向异性,呈柱状扩散。 |
| 英文摘要: |
| Objective To investigate the capacity and clinical application of diffusion tensor imaging (DTI) in multiple sclerosis (MS) of the cervical spinal cord. Methods DTI of cervical spinal cord was performed in 36 healthy volunteers and 12 cases with MS using SE-EPI. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), λ1, λ2, and λ3 values were measured. Results Both ADC and FA maps were able to show abnormal signal intensities of MS. ADC value in MS was (1473.7±227.8 )·10-6mm2/s, FA value was (467.83±43.66)×10-3, λ1 was (2024.1±283.3)×10-6mm2/s, λ2 was (1151.8±146.1)×10-6mm2/s, λ3 was (1231.0±360.9)×10-6mm2/s, and 2λ1/(λ2＋λ3) was 1.73±0.22, respectively. The values of ADC, λ1, λ2, λ3 of the MS were significantly higher than those of the control group (P＜0.05), and the values of FA and 2λ1 /(λ2＋λ3) decreased significantly compared with those of the control group (P＜0.05). The λ1 was significantly higher than λ2 and λ3 (P＜0.05). Conclusion DTI of the cervical spinal cord is a reliable tool in demonstrating the lesions of MS, in which isotropy diffusion increases evidently and anisotropy diffusion decreases obviously and diffusion shows cylindrically symmetric anisotropy characteristics. |
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