| 李天亮,邓又斌,王林,毕小军,杨好意,白姣,刘娅妮,刘冰冰.前列环素在超声心动图检测冠状动脉反应性充血扩张中作用的实验研究[J].中国医学影像技术,2005,21(5):681~683 |
| 前列环素在超声心动图检测冠状动脉反应性充血扩张中作用的实验研究 |
| Role of prostacyclin in echocardiographic evaluation of epicardial coronary vasodilation induced by reactive hyperemia in dogs |
| 投稿时间：2005-01-16 修订日期：2005-02-17 |
| DOI： |
| 中文关键词: 内皮,冠状动脉 反应性充血试验 超声心动描记术 前列环素 |
| 英文关键词:Endothelium, coronary artery Reactive hyperemia Echocardiography Prostacyclin |
| 基金项目:本课题受国家自然科学基金项目资助(30270560)。 |
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| 中文摘要: |
| 目的 评价前列环素在超声心动图检测冠状动脉反应性充血扩张中的作用。方法 健康成年杂种犬10条。应用超声心动图仪重点检测股静脉内注射环氧化酶抑制剂吲哚美辛以抑制前列环素合成前后反应性充血试验诱发的冠状动脉左前降支内径的百分变化率。结果 静脉内注射吲哚美辛后,反应性充血试验诱发的冠状动脉左前降支内径的百分变化率 较注射吲哚美辛前 明显减低(P＜0.01)。结论 超声心动图观察到的血流介导性冠状动脉内径的变化与内皮来源的扩血管物质前列环素有关。 |
| 英文摘要: |
| Objective To determine whether prostacyclin (PGI2) plays a role in the echocardiographic evaluation of the flow-dependent epicardial coronary vasodilation induced by reactive hyperemia (RH). Methods In 10 instrumented dogs, the changes of internal diameter of the left anterior descending coronary artery (LADd) were investigated before and after RH under the condition with and without blockade of PGI2 formation by intravenous injection of Indomethacin. LADd was measured using echocardiography. The percent change of LADd was calculated. Results Before intravenous injection of Indomethacin, LADd increased significantly from (2.20±0.16) mm to (2.48±0.17) mm (P＜0.001) after RH, and the percent change of LADd was (12.77±1.76)%. After intravenous injection of Indomethacin, LADd did not change significantly (P＞0.05) when compared with that before intravenous injection of Indomethacin. However, the percent change of LADd induced by RH with intravenous injection of Indomethacin was dramatically lower than that without intravenous injection of Indomethacin . Conclusion The flow-dependent dilation of the left anterior descending coronary artery detected by echocardiography is associated with endothelium-derived PGI2. Echocardiography can be used for assessment of coronary endothelial function. |
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