| 潘敏,邓又斌,毕小军,向慧娟,杨好意,常青,黎春蕾,王林,薛敏.心腔内压力对不同类型造影剂后散射强度的影响[J].中国医学影像技术,2005,21(3):351~353 |
| 心腔内压力对不同类型造影剂后散射强度的影响 |
| Effects of intracardiac pressure on backscatter intensities with different ultrasound contrasts |
| 投稿时间：2004-12-12 修订日期：2005-01-08 |
| DOI： |
| 中文关键词: 造影剂 后散射强度 压力 |
| 英文关键词:Contrast agents Backscatter intensity Pressure |
| 基金项目:本研究为国家自然科学基金资助项目(39970308)。 |
|
| 摘要点击次数: 2471 |
| 全文下载次数: 855 |
| 中文摘要: |
| 目的 采用声学密度法,观察实验动物犬心腔内不同类型造影剂后散射强度的变化,分析微气泡成分的不同对收缩期压力的敏感性。方法 经多巴酚丁胺逐步升压后,周围静脉分别注射声振白蛋白造影剂、Levovist和含氟碳造影剂,记录改变收缩期压力时不同类型造影剂的后散射二维图像,并与右室压力曲线同步。结果 收缩期压力对声振白蛋白造影剂和Levovist后散射强度之差(ED-ES)的影响差异具有显著性意义(P＜0.0001, P＜0.02),对含氟碳造 |
| 英文摘要: |
| Objective To observe the intracardiac backscatter intensities changes of different contrasts in dogs and analyze the systolic pressure sensitivity from different contrast agents using acoustic densitometry. Methods Ventricular pressure was increased by administration of dobutamine (β1-adrenoceptor agonist). And sonicated albumin microbubbles, levovist and perfluorocarbon-filled microbubbles were injected intravenously. The next step was to record the backscatter two-dimensional images at different systolic pressure and different contrasts, which synchronized with right ventricular pressure curve. Results The systolic pressure had significant effect on the differences of backscatter intensities (ED-ES) of sonicated albumin microbubbles and levovist (P＜0.0001, P＜0.02), but had little effect on that of perfluorocarbon-filled microbubbles (P=0.10). The correlation between systolic pressure and the ED-ES of sonicated albumin microbubbles was better than that of levovist (r=0.64, P＜0.0001; r=0.57,P=0.001), and that of perfluorocarbon-filled microbubbles was the least (r=0.41, P=0.07). Conclusion Pressure-sensitivity from contrast agent is subjected to the properties of the bubble shell and the inner gas. The sensitivity to the change of pressure from sonicated albumin microbubbles filled with air, encapsulating elastic shells, is better than that from levovist, but perfluorocarbon-filled microbubbles are insensitive to the change of pressure due to their rigid shells. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
