| 朱家瑞,川玲,赵文锐,高春华,许根祥,魏威.18F-FDG符合线路/CT显像对妇科肿瘤治疗方案的影响[J].中国医学影像技术,2005,21(1):121~123 |
| 18F-FDG符合线路/CT显像对妇科肿瘤治疗方案的影响 |
| Impact of 18F-FDG coincidence/CT imaging on the management of patients with gynecologic malignancies |
| 投稿时间：2004-07-10 修订日期：2004-11-04 |
| DOI： |
| 中文关键词: 妇科肿瘤 肿瘤转移 体层摄影术,发射型计算机 延迟显像 |
| 英文关键词:Gynecologic neoplasms Neoplasm metastasis Tomography, emission-computed Delayed imaging |
| 基金项目: |
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| 中文摘要: |
| 目的研究18F-FDG符合线路/CT显像对妇科肿瘤病人治疗方案的影响。方法 22例各类妇科肿瘤术后的病人共行23次18F-FDG符合线路/CT检查,并与血液肿瘤标志物测定值和CT结果比较。结果 18F-FDG符合线路/CT显像对妇科肿瘤复发、转移的灵敏度、准确率和阳性预测值分别为90.5%、91.3%和100％。FDG显像发现64个病灶,共 7例病人(30.6%)的分期和治疗方案在FDG显像之后发生改变。结论 18F-FDG符合线路/CT显像对妇科肿瘤的诊断和分期优于CT。 |
| 英文摘要: |
| Objective To investigate the impact of 18F-FDG coincidence/CT imaging on the management of patients with gynecologic malignancies. Methods Twenty-two patients with gynecologic malignancies,including 9 cervical cancer, 4 endometrial cancer, 3 ovarian cancer, 3 vagina cancer and 3 leiomyosarcoma of uterus, underwent 18F-FDG coincidence imaging. The lesions were identified on fusion images of CT and FDG by two experenced physicians using visual and semiquantitative analysis. The results of FDG coincidence imaging were compared with that of dedicated CT and various serum tumor markers. Results The sensitivity, accuracy and positive predictive value of 18F-FDG coincidence/CT imaging were 90.5%,91.3% and 100％, respectively,for detection of recurrence and metastasis of gynecologic malignancies. FDG coincidence/CT imaging found 64 lesions in 22 studies and CT found only 40 lesions(mean 3.2±3.2 vs 2.0±1.6, P=0.0298). FDG coincidence/CT imaging detected 24 more recurrent and metastastic lesions in 6 patients than dedicated CT. The stage of 7 patients were changed, in which 6 patients were upstaged and one were downstaged. The patient's management were changed in 7 cases (30.6%), resulted in a cancellation of second surgery because of the detection of previously unknown distant metastases (2 patients), additional lymph node metastases (2 patients), or the exclusion of active disease (1 patients). In another 2 patients, FDG-PET results changed the curative treatment into palliative, because of extensive metastasis. Conclusion FDG coincidence imaging superiors to CT in staging of gynecologic malignancies. FDG coincidence imaging is useful to the clinicians to choose the optimal treatment ensuring the maximum probability of recovery and being cost-effective as unnecessary medical interventions become avoidable. |
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