| 王亮,李坤成,李勇杰,卢德宏,王玉平,张国君.颞叶癫痫的1H MRSI和MRI体积测量研究[J].中国医学影像技术,2005,21(1):52~56 |
| 颞叶癫痫的1H MRSI和MRI体积测量研究 |
| 1H MRSI and MRI volumetric measurement in temporal lobe epilepsy |
| 投稿时间：2004-07-21 修订日期：2004-09-16 |
| DOI： |
| 中文关键词: 颞叶癫痫 质子磁共振波谱成像 |
| 英文关键词:Temporal lobe epilepsy 1H MR spectroscopic imaging |
| 基金项目: |
| 作者 | 单位 | E-mail | | 王亮 | 首都医科大学宣武医院放射科,神经内科,北京 100053 | wang7103@sina.com | | 李坤成 | 首都医科大学宣武医院放射科,神经内科,北京 100053 | | | 李勇杰 | 首都医科大学宣武医院功能神经外科,神经内科,北京 100053 | | | 卢德宏 | 首都医科大学宣武医院病理科,神经内科,北京 100053 | | | 王玉平 | 首都医科大学宣武医院神经内科,神经内科,北京 100053 | | | 张国君 | 首都医科大学宣武医院功能神经外科,神经内科,北京 100053 | |
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| 中文摘要: |
| 目的评价质子磁共振波谱成像(1H-MRSI)和MRI体积测量对颞叶癫痫(TLE) 的定侧诊断价值。方法 对13例单侧TLE和13例对照者行MRI和1H-MRSI扫描,测量颞叶氮-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)的浓度比率及海马结构体积。结果 TLE组8例海马结构萎缩,患侧海马结构NAA/Cr及NAA/(Cr+Cho) 显著小于对侧及对照组(前者F=5.187,P=0.012;后者F=6.731,P=0.004);患侧颞叶外侧皮层的NAA/Cr显著小于对侧(t=-2.82, P=0.015)。海马体积测量定侧敏感性为61.5%; 1H-MRSI定侧敏感性为84.6%。结论 1H-MRSI可发现颞叶广泛的代谢异常,增加定侧诊断敏感性。 |
| 英文摘要: |
| Objective To investigate the ability of 1H MR spectroscopic imaging (1H-MRSI) and MRI volumetric measurement in the lateralization of temporal lobe epilepsy (TLE). Methods Conventional MRI and 1H-MRSI were performed in 13 patients with electroencephalogram (EEG)-defined unilateral TLE and 13 normal subjects, the metabolic peak ratio of N-acetylaspartate (NAA), Creatine (Cr), Choline (Cho) and the volume of hippocampal formation (HF) were measured. Results Hippocampal atrophy was found in 8 patients of TLE. The NAA/Cr and NAA/Cho+Cr were significantly lower in the ipsilateral hippocampus than that of the contralateral and control's hippocampus (the former: F=5.187,P=0.012;the later: F=6.731,P=0.004). The NAA/Cr in the ipsilateral temporal neocortex was significantly lower than that of contralateral temporal neocortex. The sensitivity of lateralization was 61.5% with MRI volumetric measurement, 84.6% with 1H-MRSI combining hippocampus and temporal neocortex findings. Conclusion Both MRI volumetric measurement and 1H-MRSI are effective tools for lateralization of TLE. The 1H-MRSI discovers more extensive metabolic abnormality in temporal lobe, and improves the sensitivity of lateralization. |
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