| 陈敏,张云亭,张铁梅,周诚,吴小萌,蔡葵,杨正汉,王文超,赵伟峰,李飒英,王志.不同体重者葡萄糖耐量试验的中枢敏感性fMRI研究[J].中国医学影像技术,2005,21(1):42~44 |
| 不同体重者葡萄糖耐量试验的中枢敏感性fMRI研究 |
| Central sensitivity of oral glucose tolerance test in human subjects with different body weights |
| 投稿时间：2004-07-18 修订日期：2004-10-11 |
| DOI： |
| 中文关键词: 下丘脑 功能磁共振成像 葡萄糖耐量试验 |
| 英文关键词:Hypothalamus Functional magnetic resonance imaging Glucose tolerance test |
| 基金项目: |
| 作者 | 单位 | E-mail | | 陈敏 | 卫生部北京医院放射科,北京 100730
天津医科大学总医院放射科,天津 300070 | chenmin@chinaradiology.org | | 张云亭 | 天津医科大学总医院放射科,天津 300070 | | | 张铁梅 | 卫生部北京医院老年医学研究所,北京 100730 | | | 周诚 | 卫生部北京医院放射科,北京 100730 | | | 吴小萌 | 卫生部北京医院老年医学研究所,北京 100730 | | | 蔡葵 | 卫生部北京医院放射科,北京 100730 | | | 杨正汉 | 卫生部北京医院放射科,北京 100730 | | | 王文超 | 卫生部北京医院放射科,北京 100730 | | | 赵伟峰 | 卫生部北京医院放射科,北京 100730 | | | 李飒英 | 卫生部北京医院放射科,北京 100730 | | | 王志 | 卫生部北京医院放射科,北京 100730 | |
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| 中文摘要: |
| 目的观察不同体重者下丘脑对口服葡萄糖耐量试验的反应。方法 对10名肥胖者及10名正常体重者,收集口服75 g葡萄糖后的下丘脑fMRI数据,以平均灰度值方法进行图像分析处理。结果 不同体重者口服葡萄糖后在下丘脑部位均出现一过性抑制反应,但肥胖者抑制反应出现时间较正常体重者明显延迟、抑制反应强度明显减低(P<0.05),其抑制反应恢复时间明显延长(P<0.01)。结论 肥胖者下丘脑对糖刺激反应的敏感性较正常体重者降低。功能磁共振成像是确定脑特定区域功能的有效手段。 |
| 英文摘要: |
| Objective To investigate central response of hypothalamus to oral glucose tolerance test.Methods The signal of hypothalamus was monitored by fMRI for 60 minutes in 20 persons with two types of body weight (10 obese subjects and 10 normal body weight subjects) after oral glucose intake. Normal body-weight volunteers underwent repeat fMRI scan after consuming an equivalent amount of water without glucose on a separate day. The procedure for fMRI scan with water intake was the same as for glucose ingestion.Results Both normal and obese subjects demonstrated an inhibition of fMRI signal after glucose intake, but the inhibition was attenuated and delayed in obese subjects compared with that in normal subjects. The area of hypothalamus in normal subjects demonstrated no significant response after oral water ingestion. Conclusion Hypothalamus response to glucose loading in normal and obese human is different. The glucose-induced central sensitivity of hypothalamus is attenuated in obese subjects. |
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