| 王霄英,谭可,倪石磊,孙非,鲍圣德,蒋学祥.MRI和DTI评价犬急性脊髓损伤后的形态及功能改变[J].中国医学影像技术,2004,20(12):1821~1824 |
| MRI和DTI评价犬急性脊髓损伤后的形态及功能改变 |
| MR imaging and MR diffusion tensor imaging in evaluation of morphological and functional changes of acute injured canine spinal cord |
| 投稿时间：2004-08-12 |
| DOI： |
| 中文关键词: 脊髓 损伤 扩散张量成像 磁共振成像 |
| 英文关键词:Spinal cord Injury Diffusion tensor imaging Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 观察犬急性脊髓损伤后的形态和功能改变。方法 制作犬T13脊髓左半横断损伤模型。分别于损伤前、损伤后1周行MRI和DTI (SSFSE序列扫描,b=500 s/mm2, 扩散敏感梯度方向=13)检查,测量手术侧和非手术侧的ADC值及FA值,并对结果进行统计学分析。结果 正常犬脊髓左、右侧的ADC值为(1.00±0.15)×10-3mm2/s和(1.01±0.17)×10-3mm2/s,FA值为0.59±0.11和0.60±0.08,左右两侧无明显差异。脊髓损伤后手术侧ADC值升高为(1.65±0.45)×10-3mm2/s (t=4.366, P=0.001)、FA值降低为0.30±0.17(t=-3.749,P=0.003);非手术侧无明显变化。结论 DTI能对实验性脊髓损伤后的观察提供有价值的信息。 |
| 英文摘要: |
| Objective To observe the morphological and functional changes of acute injured canine spinal cord with MRI and MR diffusion tensor imaging (DTI). Methods Prior to and 1 week after injury, 12 adult canines suffered from left spinal cord hemisection at the level of T13 were examined by MRI and DTI. Axial T1 and T2-weighted images were obtained before the DTI sequence. The protocol of DTI was as following: SSFSE, TR/TE=12681/69.1 ms; ETL=84; slice thickness=5 mm with no gap; FOV=16 cm;NEX=4; matrix=128×256, b=500 s/mm2, directions of diffusion sensitive gradients=13. The apparent diffusion coefficients (ADCs) and fractional anisotropy (FA) value of the spinal cord were calculated. Results The ADCs of normal canine spinal cord at T13 level were (1.00±0.15)×10-3mm2/s and (1.01±0.17)×10-3mm2/s for the left and right sides, and the FA values of the corresponding area were 0.59±0.11 and 0.60±0.08, respectively. There were not statistically significant differences between the ADCs and FA values obtained from the left and right side (t=0.712, P=0.493; t=0.233, P=0.821, respectively). After injury, the ADC of the injured spinal cord increased to (1.65±0.45)×10-3mm2/s (t=4.366, P=0.001) and FA decreased to 0.30±0.17 (t=-3.749, P=0.003). The ADC and FA value of the contralateral spinal cord varied similarly, but with no statistically significant difference . Conclusion DTI can provide useful information of spinal cord damage in experimental spinal cord injury. |
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