| 景红丽,李方.99Tcm-HYNIC-TOC显像诊断生长抑素受体阳性肿瘤[J].中国医学影像技术,2004,20(10):1490~1493 |
| 99Tcm-HYNIC-TOC显像诊断生长抑素受体阳性肿瘤 |
| Diagnosis of somatostatin receptor-positive tumours using 99Tcm-HYNIC-TOC SPECT imaging |
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| DOI： |
| 中文关键词: 99Tcm-HYNIC-TOC 生长抑素受体显像 神经内分泌肿瘤 |
| 英文关键词:99Tcm-HYNIC-TOC Somatostatin receptor imaging Neuroendocrine tumors |
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| 中文摘要: |
| 目的 评价99TcmHYNIC-TOC显像对生长抑素受体阳性肿瘤的诊断价值。方法 86例患者进行99TcmHYNIC-TOC显像，其中神经内分泌肿瘤47例，非神经内分泌肿瘤19例，良性疾病20例。静注99TcmHYNIC-TOC 350~400 MBq后1、4 h行全身显像，阳性区域行单光子发射/X线透射断层显像(SPECT/CT)。结果 99TcmHYNIC-TOC显像阳性38例，其中神经内分泌肿瘤34例，非神经内分泌肿瘤3例，良性疾病1例，其诊断灵敏度、特异性、准确率分别是81.4%、99.5%和88.0%。结论 99TcmHYNIC-TOC显像可有效帮助诊断及定位神经内分泌肿瘤、评价手术或其他疗法的治疗效果。 |
| 英文摘要: |
| Objective To assess the diagnostic value of somatostatin receptor imaging with 99TcmHYNIC-TOC (99Tcm-hydrazinon icotinyl Tyr3 octreotide) for the localization of somatostatin receptor (SSTR) positive tumours.Methods Total 86 patients including 47 neuroendocrine tumors (NET), 19 non neuroendrocrine tumors and 20 benign lesions were enrolled in this study. Regional, whole body planer scans and SPECT/CT tomography (in positive cases) were performed at 1 and 4 hours after an intravenous injection of 350-400 MBq99TcmHYNIC-TOC.Results Positive findings were obtained in 38 of 86 patients, including 34 neuroendocrine tumors, 3 non neuroendrocrine tumors, and 1 benign lesion. The sensitivity, specificity and accuracy of 99TcmHYNIC-TOC imaging for NET were 81.4%,99.5% and 88.0%, respectively.Conclusion 99TcmHYNIC-TOC imaging is helpful for the diagnosis and localization of NET and other SSTR positive tumours. It is also useful to the detection of residual tumor after operation, and thus is helpful to the evaluation of therapeutic response. |
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