| 赵京龙,张贵祥,胡运胜,吴继红,李玉洁,周根泉,张悦萍,缪竟陶.孤立性脑转移瘤:动态增强MR表现与VEGF表达对照研究[J].中国医学影像技术,2004,20(10):1538~1541 |
| 孤立性脑转移瘤:动态增强MR表现与VEGF表达对照研究 |
| Solitary brain metastases: dynamic contrast enhanced MR imaging study correlated with VEGF expression |
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| DOI： |
| 中文关键词: 磁共振成像 图像强化 血管内皮生长因子 肿瘤转移 脑 |
| 英文关键词:Magnetic resonance imaging Image enhancement Vascular endothelial growth factor Neoplasm metastasis Brain |
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| 中文摘要: |
| 目的 探讨应用动态增强磁共振成像(DCE MRI)评价的孤立性脑转移瘤血管通透性与血管内皮生长因子(VEGF)表达的空间分布相关性。方法 24例孤立性脑转移患者于术前行DCE MRI检查，分析肿瘤不同区域强化斜率,测定标本VEGF表达。结果 肿瘤强化呈环形16例，结节状4例，靶心样4例。在环形强化中，肿瘤边缘呈高通透性,边缘VEGF高表达12例；在结节状和靶心样强化中，边缘与中心区均表现为高通透性,边缘VEGF高表达为6例，中心区高表达为5例。VEGF表达与DCE MRI强化斜率间具有显著的相关性(P<0.01)。结论 DCE MRI可以用于脑转移瘤血管生成调控的监测。 |
| 英文摘要: |
| Objective To evaluate the correlation between vascular permeability by dynamic contrast enhanced MRI (DCE MRI) and vascular endothelial growth factor (VEGF) expression in solitary brain metastasis. Methods Twenty four patients with solitary brain metastasis underwent DCE MRI examinations before operation. The slopes of the signal time curve were calculated from the central, border and peripheral parts of tumors, respectively. The VEGF expression in tumors and surrounding tissues were determined with immunohistochemistry stain. Results Rim enhancement was found in 16 cases, while nodular and target enhancement was each found in 4 cases, respectively. In the rim enhancement pattern, the border of the tumor had high enhancement slope. In 12 cases, the VEGF expression was high in the border. In the nodular pattern and the target pattern, both the border and the central part had a high permeability. In 6 cases, the VEGF expression was high in the border and in 5 cases the VEGF expression was high in central part of the tumors. These results were highly significant (P<0.01), suggesting that high VEGF expression in the tumors had a high enhancement slope. Conclusion The VEGF expression of brain metastases has a positive correlation with enhancement slope in DCE MRI. DCE MRI can be used in the surveillance of antiangiogenesis treatment of brain metastases. |
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