| 戴旭,韩铭钧,苏洪英,赵钟春,冯博,张曦彤,徐克.原发性肝细胞癌肝动脉化疗栓塞术后复发和转移的相关危险因素分析[J].中国医学影像技术,2004,20(10):1595~1598 |
| 原发性肝细胞癌肝动脉化疗栓塞术后复发和转移的相关危险因素分析 |
| The risk factors of recurrence and metastasis of primary hepatocellular carcinoma after transcatheter arterial chemo-embolization |
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| DOI： |
| 中文关键词: 肝肿瘤 栓塞,治疗性 肿瘤复发,局部 危险因素 |
| 英文关键词:Liver neoplasms Embolization, therapeutic Neoplasms recurrence, local Risk factors |
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| 中文摘要: |
| 目的 研究原发性肝细胞癌(HCC)化疗栓塞术后的复发转移类型并评价与复发转移相关的危险因素。方法 回顾性分析245例接受二次以上栓塞治疗的原发性HCC病例,根据影像表现将复发转移分为原位复发、肝内复发、门脉浸润及远隔转移四种类型,进行统计分析。结果 245例病人共复发133例,实际复发率54.29%。133例复发组中复发176例次,其中原位复发、肝内复发、门脉浸润及远隔转移分别占13.07%、 35.23%、 32.39%及 19.32%。HBsAg阳性,AFP升高(大于或等于400 IU/ml),脾大,肝功差(Child B,C级)及肿瘤病灶多血供(P<0.05)是HCC栓塞后复发的危险因素,其中HBsAg阳性、肿瘤多血供及不良肝功与复发的关系尤为密切(P<0.01)。结论 原发性HCC如合并有HBsAg阳性,AFP升高,脾大,肝功Child B、C级,及病灶多血供等因素,应是栓塞后复发转移的高危人群,并尽早复查复治。 |
| 英文摘要: |
| Objective To analyze the risk factors of recurrence of hepatocellular carcinoma (HCC) after transcatheter arterial chemo-embolization (TACE). Methods Total 245 cases of HCC treated with TACE were analyzed retrospectively. The radiographic findings combined with clinical data were used to analyze the risk factors of recurrence. Results Of 245 cases, 176 recurrences developed in 133 cases, the actual recurrence rate was 54.29%. Intrahepatic recurrence was the most common type, and the ratio in recurrence group was 35.23%. The ratio of recurrence in group of portal vein invasion, extrahepatic metastasis and recurrence in situ were 32.39%, 19.32% and 13.07%, respectively. Univariate analysis of recurrence indicated that hepatitis B surface antigen, rising serum AFP level (≥400 IU/ml), larger spleen, worse hepatic function (Child B or C) and hypervascular focus were the risk factors of recurrence (P<0.05). Conclusion The risk factors linked to recurrence of HCC are not only underlying liver state as hepatitis B, worse liver function, larger spleen, but also the blood supply type and AFP level. |
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