| 王苇,李澄,陈建,蒋学祥,薛贞龙,王霄英,刘德志,杜芳,孙玮.流动敏感交互式反转恢复磁共振灌注成像技术及其初步临床应用[J].中国医学影像技术,2004,20(8):1289~1292 |
| 流动敏感交互式反转恢复磁共振灌注成像技术及其初步临床应用 |
| Flow-sensitive alternating inversion recovery MR perfusion technique: the initial experience of clinical application |
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| DOI： |
| 中文关键词: 动脉血质子自旋标记 磁共振灌注 脑血流 |
| 英文关键词:Arterial spin labeling Magnetic resonance perfusion Cerebral blood flow |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨流动敏感交互式反转恢复(FAIR)磁共振灌注成像技术的临床应用价值。方法 对10名志愿者和18例脑肿瘤患者进行FAIR技术和磁敏感对比剂动态增强 (DSC) MR脑灌注成像。缺血性脑梗死患者45例,其中超急性期8例,按照自行制定的脑卒中方案进行检查,包括DWI和FAIR序列。结果 10名志愿者FAIR-△S和DSC-CBV都清楚显示随血流灌注的变化颅内灰质、白质和灰质团块的分布。18例脑肿瘤患者FAIR-△S显示11例肿瘤实质部分△S超过周围正常脑组织,3例△S与周围脑组织相仿,4例△S低于周围脑组织,所得结果与DSC-CBV一致。缺血性脑梗死45例在DWI均有阳性发现,39例FAIR发现明确的血流灌注减低。结论 FAIR灌注技术无需注射造影剂,是常规MR成像技术良好的补充,有重要的临床实用价值。 |
| 英文摘要: |
| Objective To evaluate the clinical value of flow-sensitive alternating inversion recovery (FAIR) MR perfusion technique. Methods Cerebral perfusion imaging was carried out in 10 healthy volunteers and 18 patients with cerebral tumors using FAIR and dynamic susceptibility contrast (DSC) technique simultaneously. Forty-five ischemic cerebral infarct patients, including 8 hyperacute cases were performed with scheduled scans for stroke, including FAIR and diffusion weighted imaging (DWI). Results In volunteers, good gray/white-matter contrast was observed in FAIR-△S and DSC-CBV maps. In 18 tumor patients, FAIR-△S values of tumors in 11 patients were higher than that of surrounding normal brain tissue, similar in 3 patients and lower in 4 patients. Results of DSC-CBV were consistent with that of FAIR-△S. In all 45 ischemic stroke patients, DWI abnormalities were detected in all cases while areas with perfusion abnormalities were observed in 39 patients by FAIR technique. Conclusion Being a technique for depicting cerebral perfusion without the requirement of exogenous contrast, FAIR is complementary to routine MR imaging in the assessment of cerebral perfusion. |
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