| 华琦,李东宝,皮林,许骥.G蛋白β3亚单位基因C825T多态性与高血压患者左室肥厚的相关性[J].中国医学影像技术,2004,20(7):1035~1038 |
| G蛋白β3亚单位基因C825T多态性与高血压患者左室肥厚的相关性 |
| Correlation between G protein β3 subunit gene polymorphism and left ventricular hypertrophy in hpertensive patients |
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| DOI： |
| 中文关键词: G蛋白 基因多态性 原发性高血压 左室肥厚 |
| 英文关键词:G protein Gene polymorphism Essential hypertension Left ventricular hypertrophy |
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| 中文摘要: |
| 目的 探讨G蛋白β3亚单位基因C825T多态性与中国人原发性高血压(EH)及左室肥厚的关系。方法 采用多聚酶链式反应结合限制性内切酶片段长度多态分析方法检测147例健康人和321例高血压患者的G蛋白β3亚单位C825T多态性及用超声测定高血压患者的左室重量(LVM)、左室重量指数(LVMI)、室间隔厚度(IVST)。结果 高血压组G蛋白β3亚单位C825T多态性中基因型频率(CC 28.7%、CT 52%、TT 19.3%)、等位基因频率(C 54.672%、T 45.33%)与正常对照组基因型频率(CC 27.2%、CT 46.9%、TT 25.9%)、等位基因频率(C 50.7%、T 49.3%)比较无显著性差异(P>0.05);CT+TT基因型携带者LVM(265.25±54.34 g)、LVMI(144.42±24.73 g/m2)、IVST(1.169±0.16 cm)均高于CC基因型携带者(238.81±39.49 g、134.36±18.33 g/m2、1.10147±0.14 cm),有统计学差异(P<0.05)。结论 G蛋白β3亚单位基因C825T多态性可能与中国人原发性高血压发病无关,825T等位基因可能是高血压患者左室肥厚的遗传危险因素。 |
| 英文摘要: |
| Objective To investigate the relationshiop between G protein β3 subunit gene polymorphism and essential hypertension and left ventricular hypertrophy in a chinese population. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of G protein of β3 subunit gene in 147 normotensive controls and 321 hypertensive patients. Left ventricular mass (LVM), left ventricular mass index (LVMI), intraventricular septem thicks (IVST) were measured by echocardiography in hypertensive patients. Results There were no significant differences of the GNB3 gene C825T polymorphism genotypes and alleles between hypertensive patients (CC 28.7%, CT 52%, TT 19.3%, C 50.7%, T 49.3%) and normotensive controls (CC 27.2%, CT 46.9%, TT 25.9%, C 50.7%, T 49.3%). LVM (265.25±54.34 g), LVMI (144.42±24.73 g/m2), IVST (1.169±0.16 cm)of CT + TT genotype were higher than CC genotype (238.81±39.49 g, 134.36±18.33 g/m2, 1.10147±0.14 cm) in hypertensive patients. Conclusion The C825T polymorphism of G protein β3 subunit was not associated with EH in Chinese. 825T allele of GNB3 gene probobly was a genetic risk factor of left ventricular hypertrophy in hypertensive patients. |
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