| 曹玮,段云友,曹铁生,王执民,张洪新,吕发勤,刘禧.阿霉素热碘油栓塞对兔肝VX2肿瘤的血流动力学影响[J].中国医学影像技术,2004,20(7):1010~1013 |
| 阿霉素热碘油栓塞对兔肝VX2肿瘤的血流动力学影响 |
| Heat ADM lipidol embolization influence on hepatic tumor hemodynamics in rabbits |
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| DOI： |
| 中文关键词: 多普勒超声检测 VX2 肝肿瘤 阿霉素 碘油 热栓塞 兔 |
| 英文关键词:Doppler ultrasonography VX2 Hepatic tumor ADM Lipidol Heat-embolization Rabbit |
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| 中文摘要: |
| 目的 利用多普勒超声研究阿霉素热碘油栓塞治疗后兔肝VX2肿瘤及肝脏的血流动力学变化。方法 30只荷瘤兔,随机分为3组,分别采用37℃生理盐水、37℃阿霉素碘油及60℃阿霉素热碘油经兔肝动脉灌注治疗,1周后多普勒超声观察肿瘤血供及肝动脉、门静脉血流动力学变化,检测结果与治疗前相应血管的多普勒参数进行比较。肝动脉及肿瘤血管造影结果作为金标准。结果 阿霉素热碘油灌注栓塞后肝动脉血流速度明显降低(P<0.05),阻力指数增大(P<0.05),门静脉血流速度及内径均无明显变化(P>0.05);治疗前,所有病灶能量及彩色多普勒均可检测出瘤内及瘤周较丰富血流信号,治疗后显示阿霉素热碘油组瘤内及瘤周血流信号均明显减弱,部分消失。结论 阿霉素热碘油栓塞可更有效地阻断兔肝VX2肿瘤供血,多普勒超声可显示该血流的变化,便于对阿霉素热碘油栓塞治疗肝肿瘤的疗效进行及时评价。 |
| 英文摘要: |
| Objective To study the hemodynamic changes in the rabbit liver and hepatic VX2 tumor after treatment by lipidol heat-embolization with Doppler ultrasonography. Methods Thirty rabbits with VX2 hepatic tumors were divided into three groups randomly. Each group was infused with 37℃ saline, 37℃ ADM-lipidol and 60℃ ADM-lipidol respectively via hepatic artery. The hemodynamic indexes of the tumor, hepatic artery and portal vein were recorded with Doppler ultrasonography 1 week after perfusion. These findings were compared with those before treatment. Results The group dealt with 60℃ ADM-lipidol showed that hepatic artery velocities were lower obviously than those before treatment (P<0.05), and the resistance indexes were larger (P<0.05). However the velocities and the diameters of portal vein were no change compared with those before treatment (P>0.05). The blood flow signals in and para-tumors were richer before perfusion with power and color Doppler ultrasound. These blood flow signals became less significantly, even disappeared than those before heat-embolization. Conclusion The heat-embolization with 60℃ ADM-lipidol can block the blood supplement of hepatic VX2 tumors in rabbit effectively. The blood flow changes can be detected with power and Doppler ultrasound, so it benefits for therapy effect evaluation of ADM-lipidol heat-embolization in hepatic tumor in time. |
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