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樊金辉,徐克,戴旭,卢涛,李红.碘油-化疗药栓塞剂的颗粒直径和稳定性对TACE疗效影响的实验研究[J].中国医学影像技术,2004,20(4):510~512

碘油-化疗药栓塞剂的颗粒直径和稳定性对TACE疗效影响的实验研究

Diameter and stability of the lipoidol-chemotherapeutic drugs emulsion: the impact factors on TACE in treating neoplasm of liver

DOI：

中文关键词: VX2肝脏移植瘤经导管肝动脉化疗栓塞术乳化碘油-化疗药栓塞剂直径稳定性

英文关键词:VX2 implanted liver neoplasm TACE Emulsification Lipoidol-chemotherapeutic drugs emulsion Diameter Stability

基金项目:

作者	单位
樊金辉	中国医科大学附属第一医院放射科,辽宁沈阳 110001
徐克	中国医科大学附属第一医院放射科,辽宁沈阳 110001
戴旭	中国医科大学附属第一医院放射科,辽宁沈阳 110001
卢涛	中国医科大学附属第一医院放射科,辽宁沈阳 110001
李红	中国医科大学附属第一医院放射科,辽宁沈阳 110001

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中文摘要:

目的以兔VX2肝脏移植瘤模型为对象,探讨不同颗粒直径和稳定性的碘油-化疗药栓塞剂对TACE疗效的影响。方法 36只VX2肝脏移植瘤大白兔随机平均分成6组。肝脏肿瘤移植术后3周行MSCT检查测定肿瘤体积(V1),后即行腹部切开术,将导管插入肝动脉,按以下治疗方案进行介入治疗:(A,B组)A溶液+三氧化二砷+超液化碘油。(C,D组)B溶液+三氧化二砷+超液化碘油。(E,F组)C溶液+三氧化二砷+超液化碘油。其中A,C,E组采用手摇动10次混匀,B, D, F组采用超声乳化方法混匀。TACE 3周后再行MSCT检查测定肿瘤体积(V2)。结果分别比较经TACE治疗三周后的肝脏肿瘤体积(V2),即A与B,C与D,E与F,各自组间比较均有统计学差异(P＜0.05)。结论当溶解化疗药的溶剂比重与超液化碘油相同时,碘油-化疗药栓塞剂稳定性最好。超液化碘油-化疗药栓塞剂的直径与稳定性对TACE的疗效有影响作用。

英文摘要:

Objective To investigate the influence of transcatheter arterial chemoembolization (TACE) in implanted VX2 liver neoplasm in rabbits by using lipoidol-chemotherapeutic drugs emulsion of different diameter and stability. Methods Thirty-six rabbits bearing VX2 implanted hepatoma were randomly divided into six groups. The tumor volume (V1) was measured by MSCT three weeks after the implantation. Following the laparotomy and putting catheter into the liver artery, the protocols of interventional therapy to be performed included: solution A+AS₂O₂+lipiodol used for group A and B, solution B+AS₂O₂+lipiodol used for group C and D, solution C+AS₂O₂+lipiodol used for group E and F. The drugs in the group A, C, E were mixed by hands, shaking ten times. The drugs in the group B, D, F were mixed by ultrasound shaking. Then tumor volume (V2) was measured again by MSCT three weeks after TACE. Results Comparing the volume of the liver neoplasm, A with B, C with D, E with F three weeks after TACE, there was statistical significance among the three groups (P＜0.05) respectively. Conclusion It showed that when the gravity of the solvent which solved the chemotherapeutic drugs was similar to that of the lipiodol, the stability of the emulsion was the best. The diameter and stability of the lipoidol-chemotherapeutic drugs emulsion were the important factors in TACE for treating human hepatocellular carcinoma.

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