| 卫静,邹利光,廖翠薇,文利,可金星.肝细胞癌MRI动态增强表现的血供基础研究[J].中国医学影像技术,2004,20(4):506~509 |
| 肝细胞癌MRI动态增强表现的血供基础研究 |
| Study of blood on the manifestation of hepatocellular carcinoma on dynamic contrast-enhanced MR imaging |
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| DOI： |
| 中文关键词: 肝细胞癌 磁共振成像 动态 微血管密度 大鼠 |
| 英文关键词:Hepatocellular carcinoma Magnetic resonance imaging Dynamic Microvessel density Rat |
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| 中文摘要: |
| 目的 明确肝细胞癌MRI动态增强表现的微血管基础。方法 用二乙基亚硝胺长期小剂量灌喂大鼠诱发肝细胞癌,于不同时间行MRI动态增强扫描,并且在相应部位取材做病理、电镜及MVD测定。结果 41个结节做MRI动态增强扫描,绘制时间-信号强度曲线,可见曲线形态与肿瘤MVD有关,快速上升型曲线肿瘤的MVD值高,缓慢上升型曲线肿瘤的MVD值低。结论 MRI动态增强扫描可以客观的反映肿瘤的血供情况,有助于临床进一步治疗。 |
| 英文摘要: |
| Objective To clarify the microvessel basis of of hepatocellular carcinoma (HCC) in rats on dynamic contrast-enhanced MRI. Methods HCC was induced chronically with low dose of Diethylnitrosamine in rats. Rats received dynamic contrast-enhanced MRI examinations in various times, then specimens were drawed for observed with light microscope, transmission electron microscope and microvessel density (MVD) matching with the lesion showed on the MRI. Results Forty-one nodules were detected on dynamic contrast-enhanced MRI, and the time-intensity curve was analysed. The shape of curve of tumor was correlated with the MVD of tumor, the tumor had higher MVD when its curve increased rapidly in early phase, and had low MVD when its curve increased gradually with time throughout the examination. Conclusion Dynamic contrast-enhanced MR imaging can objectively reflect the information of blood supply of tumor, it is useful for further clinical treatment. |
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