| 张曦彤,徐克,刘晋,高沁怡,关超,邱雪杉.103Pd金属支架在TIPS中的初步实验观察[J].中国医学影像技术,2004,20(3):375~377 |
| 103Pd金属支架在TIPS中的初步实验观察 |
| Preliminary observation on 103 Pd radioactive stent for transjugular intrahepatic portalsystemic shunt |
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| DOI： |
| 中文关键词: 门体分流术,经颈脉肝内 支架,放射性 放射学,介入性 实验动物模型 |
| 英文关键词:Portasystemic shunt, transjugular intrahepatic Stent, radioactive Experimental animal models Radiology interventional |
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| 中文摘要: |
| 目的 评价103Pd放射性支架防治TIPS分流道狭窄的可行性。方法 6只家猪分成两组建立TIPS模型。3只应用标有103Pd的国产不锈钢Z型支架(放射剂量250 μCi),3只为非放射性同种材质支架。术后4、8周行门脉造影及病理组织学检查。结果 术后4周,两组各复查一只,分流道均闭塞。术后8周,两组各复查二只,除对照组一例分流道狭窄外,余3例分流道均闭塞。103Pd组3例分流道内外可见大量胶原纤维和纤维细胞产生,以支架金属丝周围最显著,无血栓形成。对照组除纤维组织增生外,2例分流道内形成血栓和胆汁染色现象。两组分流道各段组织增生厚度对比,以103Pd组增生最明显(P<0.05)。结论 250 μCi放射活性水平的103Pd支架未能改善TIPS分流道通畅率;可诱发明显纤维组织增生,主要发生在肝实质段分流道内。 |
| 英文摘要: |
| Objective To evaluate the availability of 103Pd radioactive γ-emitting stent in preventing stenosis of TIPS. Methods Home-made stainless steel Z stent γ-emitting 103Pd with an activity level of 250 μCi and nonradioactive Z stent were implanted in domestic swine respectively in two TIPS groups. We performed portal venography followed by histopathologic examination of TIPS shunt at the 4th and 8th week. Results One from each group had a occluded shunt at the 4th week after operation. Among the four swine examined at the 8th week, three occluded shunt were found excepting one stenosed shunt in control group. In radiation-treated group, the proliferation of collagen fibril and fibroblast were abound in TIPS shunt especially around the metalic struts. No thrombosis occurred in the shunts. Besides of fibrinous tissues hyperplasia, two TIPS shunts had thrombosis and bile staining in control group. Comparing the thickness of each section of TIPS shunt between two groups, proliferation in 103Pd radioactive stent group was prominent. Conclusion The 103Pd radioactive stent with an activity level of 250 μCi do not improve the patency of TIPS. 103Pd stent can induce obvious fibrous tissue proliferation mainly in the section of liver parenchyma shunt and lead to the occlusion of TIPS. |
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