| 程文 综述,张青萍 审校.超声在基因治疗方面的研究进展[J].中国医学影像技术,2004,20(1):150~152 |
| 超声在基因治疗方面的研究进展 |
| Ultrasound for gene therapy |
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| DOI： |
| 中文关键词: 超声 基因治疗 空化效应 细胞通透性 |
| 英文关键词:Ultrasound Gene therapy Cavitation Cell permeability |
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| 摘要点击次数: 2023 |
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| 中文摘要: |
| 超声通过其空化效应可增加细胞膜的通透性,进而能促使外源基因进入细胞,增强了基因在体外细胞和体内细胞的转染和表达水平。超声的此种特性,与超声的照射条件,如 机械指数、脉冲重复频率、照射时间等有关。超声被认为是增强非病毒载体基因治疗效率的新方法。 |
| 英文摘要: |
| Ultrasound can increase cell permeability by cavitation, so that it can improve the efficiency of gene transfection and transgene expression in cells in vitro and in vivo. Ultrasound-assisted gene delivery is associated with the parameters of ultrasound exposure, such as mechanical index, pulse repetition frequency, time of exposure, and so on. Ultrasound has great promise as a novel approach to improve the efficiency of nonviral gene delivery. |
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