| 张永高,高剑波,杨学华,张谢夫,张云汉,郭华,陈学军,周志刚,杨晓鹏,岳松伟.大肠癌浆膜侵犯螺旋CT征象与MVD、nm23-H1表达间关系的研究[J].中国医学影像技术,2004,20(1):7~10 |
| 大肠癌浆膜侵犯螺旋CT征象与MVD、nm23-H1表达间关系的研究 |
| Correlation between spiral CT features of serosa invasion and expression of MVD and nm23-H1 in colorectal carcinoma |
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| DOI： |
| 中文关键词: 大肠肿瘤 体层摄影术,X线计算机 微血管密度 nm23-H1 |
| 英文关键词:Colorectal neoplasms Tomography, X-ray computed Microvessel density nm23-H1 |
| 基金项目: |
| 作者 | 单位 | | 张永高 | 郑州大学一附院放射科,河南 郑州 450052 | | 高剑波 | 郑州大学一附院放射科,河南 郑州 450052 | | 杨学华 | 郑州大学一附院放射科,河南 郑州 450052 | | 张谢夫 | 郑州大学一附院普外科,河南 郑州 450052 | | 张云汉 | 郑州大学一附院病理科,河南 郑州 450052 | | 郭华 | 郑州大学一附院放射科,河南 郑州 450052 | | 陈学军 | 郑州大学一附院放射科,河南 郑州 450052 | | 周志刚 | 郑州大学一附院放射科,河南 郑州 450052 | | 杨晓鹏 | 郑州大学一附院放射科,河南 郑州 450052 | | 岳松伟 | 郑州大学一附院放射科,河南 郑州 450052 |
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| 中文摘要: |
| 目的 探讨大肠癌浆膜侵犯螺旋CT征象与MVD及nm23-H1表达间的关系。方法 对42例螺旋CT征象上不同浸润深度的大肠癌组织采用SP免疫组化法进行nm23-H1表达的检测,并计数MVD。结果 在螺旋CT征象上浆膜侵犯有、无组,MVD比较有统计学意义(t'=-2.852, P=0.007),两组nm23-H1的阳性表达无统计学意义(χ2=0.318, P=0.710),nm23-H1表达阳性组和阴性组的MVD比较有统计学意义(t=-2.149, P＝0.038)。结论 血管生成可能在大肠癌浸润生长中起促进作用;nm23-H1可能是肿瘤血管生成的抑制因子;螺旋CT征象上显示癌肿肠周脂肪层有线样、条索状高密度影并不一定提示其具有更高的远处转移倾向。 |
| 英文摘要: |
| Objective To study the relation between the expressions of nm23-H1 as well as MVD and SCT features in colorectal carcinoma with serosa invasion. Methods Relate to the various invasion depth of colorectal carcinoma in SCT features, analysis of the MVD and the expression of nm23-H1 in 42 cases was obtained by using immunohistochemical streptavidin peroxidase conjugate method. Results In the serosa-invasion group and the non-serosa-invasion group of 42 cases in SCT features, the microvessel densities was a remarkable difference (t'=-2.852, P=0.007) and the positive rates of nm23-H1 was no remarkable difference (χ2=0.318, P=0.710) between them. The difference of microvessel densities between the nm23-H1-positive group and the nm23-H1-negative group was significant (t=-2.149, P＝0.038). Conclusion ①Angiogenesis may play a promotive role in the progression of colorectal carcinoma. ②nm23-H1 is maybe a inhibitory factor in angiogenesis of colorectal carcinoma. ③The SCT features of serosa-invasion which show line and stripe feature in colorectal carcinoma don't indicate the tumor has more tendency in metastasis. |
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